
#525: Multi-Cancer Early Detection Testing
From The Curbsiders Internal Medicine Podcast by The Curbsiders Internal Medicine Podcast
May 18, 2026 · 49 min
About this episode
The episode discusses the real-world utility and implications of Multi-Cancer Early Detection tests with expert insights from Dr. Margaret Tempero.
Cut through the hype of Multi-Cancer Early Detection (MCED) tests and learn how to counsel patients on the real-world utility, false-positive risks, and the "stage shift" debate of these emerging blood assays. We are joined by world-renowned oncologist Dr. Margaret Tempero , UCSF Cancer Early Detection and Interception , to discuss whether these tests are truly ready for clinical prime time. Claim CME for this episode at curbsiders.vcuhealth.org ! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Show Segments 00:00 Introduction 01:57 Current Cancer Screening Programs 06:05 Emerging Blood-Based Cancer Tests 11:55 Test Characteristics and Limitations 18:05 Practical Considerations for Patients 25:33 Direct-to-Consumer Testing/Whole Body MRIs 36:46 Navigating Positive Test Results 45:10 Anxiety and Patient Education 47:08 Future Directions in Cancer Screening Outro Credits Producer, Writer, Show Notes, Infographic, Cover Art: Molly Heublein MD Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP Reviewer: Sai S Achi MD,MBA,FACP Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Margaret Tempero…
People in this episode
Hosts: Matthew Watto, Paul Williams
Guest: Margaret Tempero
Topics covered
- Multi-Cancer Early Detection
- cancer screening
- blood tests
- patient counseling
- false-positive risks
- clinical utility
Keywords
- MCED
- cancer detection
- blood assays
- screening programs
- patient education
- test limitations
Mentioned in this episode
Organizations: UCSF Cancer Early Detection and Interception, Grail, Global Bio Access Fund, Bristol Myers Squibb, Astra Zeneca
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