The Dr. Ardis Show | Top 20 Drugs: Antidepressants| Episode 07.08.2026

The Dr. Ardis Show | Top 20 Drugs: Antidepressants| Episode 07.08.2026

From The Dr. Ardis Show Podcast by Dr Bryan Ardis

July 8, 2026 · 1h 14m

About this episode

Dr. Bryan Ardis discusses the top prescribed antidepressants in America and their associated risks, while highlighting nutrient deficiencies linked to depression and anxiety.

Dr. Bryan Ardis continues his Top 20 Prescribed Drugs of 2025 series, this week the three most prescribed antidepressants in America: Sertraline (Zoloft), Escitalopram (Lexapro), and Trazodone (Desyrel). Walking through the Cleveland Clinic and drugs.com package inserts slide by slide, Dr. Ardis breaks down how each drug works as an SSRI, the FDA's black box suicide-risk warning carried by all three, and the extensive list of published psychiatric, cardiovascular, gastrointestinal, dermatological, and reproductive side effects tied to each medication. He also highlights research showing the elderly, not just adolescents, carry the highest risk of suicidal ideation on these drugs, and points out that even the Cleveland Clinic admits antidepressants do not treat the underlying cause of depression. From there, Dr. Ardis pivots to the research-backed nutrient deficiencies most closely linked to depression and anxiety: vitamin D, iodine, quercetin, vitamin K2, and vitamin B9 (methyl folate). He walks through peer-reviewed studies showing these nutrients rival or outperform standard antidepressants in clinical trials, with none of the associated side effects. Nature Wins Products…

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