Brain Inflammation and Food: Dr. Austin Perlmutter on the Gut-Brain Connection, Brain Fog, and What to Eat for Better Cognitive Health

Brain Inflammation and Food: Dr. Austin Perlmutter on the Gut-Brain Connection, Brain Fog, and What to Eat for Better Cognitive Health

June 2, 2026 · 32 min · Season 1 · Episode 145

About this episode

Dr. Jolene Brighten discusses the connection between brain inflammation and food with Dr. Austin Perlmutter, exploring how nutrition impacts cognitive health.

I'm hosting a live PMDD Relief Workshop on June 10th, free when you pre-order ADHD and Women. Get your spot at https://drbrighten.com/pmdd What if your brain fog, low mood, and poor focus were not just “in your head,” but connected to what is happening in your immune system, gut microbiome, and daily food choices? In this episode of The Dr. Brighten Show, Dr. Jolene Brighten sits down with Dr. Austin Perlmutter to unpack the connection between brain inflammation and food, including why the brain is literally built from the nutrients you eat, how added sugar may influence systemic inflammation, and why the gut-brain connection is one of the most important conversations in brain health right now. Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, and Managing Director of Big Bold Health. His work focuses on brain and body health, including the biological roots of mental and physical “stuckness,” how environmental factors shape cognitive and emotional well-being, and how plant nutrients may impact human aging through epigenetics. His work has reached millions through media outlets including PBS, Rolling Stone, and NPR. In this…

People in this episode

Host: Dr. Jolene Brighten

Guest: Dr. Austin Perlmutter

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Mentioned in this episode

Organizations: Big Bold Health

Books & works: ADHD and Women

Places: New York

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