Ep 105 - The RSI Trial

About this episode

Dr Jarvis discusses the implications of the RSI trial comparing ketamine and etomidate for tracheal intubation.

You've read about how this groundbreaking trial on ketamine vs etomidate for RSI "Changes Everything!" on the socials. Or perhaps "it's horribly biased and unnecessary... we're already knew all this!". Why? Well.. social media. Listen in as Dr Jarvis discusses not just this trial, but what the evidence landscape was before it was released. Why was it done, how was it done, what does it show, and how can we integrate it into our practice? Citations: 1. Casey JD, Seitz KP, Driver BE, et al. Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults. N Engl J Med. Published online December 9, 2025. 2. Jabre P, Combes X, Lapostolle F, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet. 2009;374(9686):293-300. 3. Matchett G, Gasanova I, Riccio CA, et al. Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial. Intensive Care Med. 2022;48(1):78-91. 4. Koroki T, Kotani Y, Yaguchi T, et al. Ketamine versus etomidate as an induction agent for tracheal intubation in critically ill adults: a Bayesian meta-analysis. Crit Care. 2024;28(1):48. 5. Yeh RW…

People in this episode

Guest: Dr Jarvis

Topics covered

• RSI Trial
• Ketamine vs Etomidate
• Tracheal Intubation
• Critical Care
• Evidence-Based Medicine

Keywords

• RSI
• Ketamine
• Etomidate
• Tracheal Intubation
• Critical Care
• Evidence
• Trial

Mentioned in this episode

Organizations: Long Pause Media, FlightBridgeED

Books & works: N Engl J Med, Lancet, Intensive Care Med, Crit Care, BMJ

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