#46 - Jake Orthwein | Unraveling the Dream: Psychedelics, Meditation, and the Brain

#46 - Jake Orthwein | Unraveling the Dream: Psychedelics, Meditation, and the Brain

April 7, 2026 · 1h 22m

About this episode

Jake Orthwein discusses the intersection of psychedelics, meditation, and neuroscience in relation to consciousness and the good life.

Jake Orthwein is the creator of Frame Problems , a video essay channel on science, art, philosophy, politics, and culture. In this episode, Jake talks about his upcoming film for Sam Harris ‘s mindfulness app Waking Up. We explore the latest neuroscience on consciousness and how it might explain the psychedelic experience, religious phenomenology, meditation and what it all means for a good life. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit themetagame.substack.com

People in this episode

Host: Daniel Kazandjian

Guest: Jake Orthwein

Topics covered

Mentioned in this episode

Organizations: Frame Problems, Sam Harris, Waking Up

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