
391: Breaching the IBD efficacy ceiling, and sham surgeries
From The Readout Loud by STAT
March 5, 2026 · 30 min
About this episode
The episode discusses the challenges in improving drug efficacy for inflammatory bowel disease and the FDA's approach to rare disease treatments with insights from Cameron Turtle of Spyre Therapeutics.
Will drugmakers finally be able to breach the efficacy ceiling in inflammatory bowel disease? And is the Food and Drug Administration being flexible enough with rare disease treatments? Spyre Therapeutics CEO Cameron Turtle joins the podcast to discuss his company's experimental IBD medications, and whether the drug industry is scraping the barrel in the search for better treatments. We also discuss the latest news in the life sciences, including the ongoing debate between the FDA and UniQure over its Huntington's disease therapy, as well as Moderna's mammoth patent settlement.
People in this episode
Guest: Cameron Turtle
Topics covered
- inflammatory bowel disease
- drug efficacy
- FDA regulations
- rare disease treatments
- life sciences news
Keywords
- IBD
- drugmakers
- FDA
- rare diseases
- Huntington's disease
- Moderna
- patent settlement
Mentioned in this episode
Organizations: Food and Drug Administration, Spyre Therapeutics, UniQure, Moderna
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