Age-less Revolution: Why We Age — From DNA Damage to Cellular Energy — and How Longevity Medicine Is Rewriting the Rules

About this episode

This episode explores the biology of aging, focusing on cellular damage, mitochondrial health, and the role of NAD⁺ in longevity medicine.

Why do we age? Is it simply the passage of time — or something far more precise, and far more modifiable? In this episode of The Science of Age-less Living , Dr. Ethan Hausman-Marquis takes you deep into the real biology of aging, revealing why growing older is not an inevitable countdown, but a consequence of accumulated cellular damage and declining repair capacity. You’ll learn why aging is best understood as a systems-level failure — a breakdown in information, energy, and repair — rather than a single disease. We explore how DNA damage accumulates over time, why epigenetic regulation drifts and causes identical twins to age differently, and how loss of proteostasis leads to protein misfolding and neurodegenerative disease. The episode then zooms into the cell’s power plants: mitochondria. You’ll discover why mitochondrial dysfunction may be the true biological clock of aging, how redox imbalance and failed mitophagy turn cells into energy-starved “zombie” states, and why restoring mitochondrial health has such wide-ranging effects on longevity. We break down the critical role of NAD⁺ — the cell’s universal energy currency — explaining how its age-related decline impairs DNA…

People in this episode

Host: Dr. Ethan Hausman-Marquis

Topics covered

• aging
• longevity medicine
• cellular damage
• mitochondrial dysfunction
• DNA repair
• epigenetics
• proteostasis

Keywords

• aging
• longevity
• mitochondria
• DNA damage
• epigenetics
• proteostasis
• NAD+
• peptides

Mentioned in this episode

Products: NAD⁺, peptides

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