23 AI Trends keeping me up at night

23 AI Trends keeping me up at night

April 1, 2026 · 32 min

About this episode

Greg Isenberg discusses various AI trends and opportunities that are influencing the startup landscape.

I go solo on this episode to walk through the full list of AI trends and opportunities keeping me up at night — literally. From the one-hour company stack to ambient businesses, vertical AI, the agent economy, and the real security threats I see coming, I cover what I believe is the most asymmetric window in startup history. I share the frameworks I use to think about what to build, what to avoid, and why acting now matters more than waiting for things to settle down. Timestamps 00:10 – Intro 01:09 – 1) The One-Hour Company Stack 02:09 – 2) Old vs. new startup timeline 03:58 – 3) Ambient businesses and autonomous companies 05:18 – 4) The agent economy timeline 07:17 – 5) Agent hiring Agents 08:01 – 6) The Vertical Agent Map 09:39 – 7) Vertical AI vs. Vertical SaaS 10:53 – 8) Boring goldmine verticals 11:40 – 9) SaaS Pricing Evolution 13:26 – 10) Seat-Based vs Outcome-Based 14:51 – 11) The SaaS graveyard 16:04 – 12) The scarcity flip 17:03 – 13) The Premium Stack 18:21 – 14) The experience economy boom 18:59 – 15) Founder-agent fit 20:32 – 16) Ghost team org chart 21:56 – 17) The micro monopoly math 24:00 – 18) Agent attack surface 25:19 – 19) Agent Injection vs Phishing 26:34 –…

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Host: Greg Isenberg

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