About this episode

This episode discusses Bosma arhinia microphthalmia syndrome and the use of iPSCs to study its developmental basis.

Bosma arhinia microphthalmia syndrome (BAMS) is a rare genetic disorder resulting in babies born without a nose, along with eye and reproductive anomalies. Our guests today investigated the developmental basis of this distinct defect using induced pluripotent stem cells (iPSCs) derived from patients with BAMS. They assessed the differentiation potential of BAMS patient-derived iPSCs into cranial placode cells, a group of progenitor cells that contribute to the formation of the nasal epitheliu...

People in this episode

Host: Janet Rossant

Topics covered

• genetic disorders
• stem cells
• developmental biology
• cranial placode cells
• induced pluripotent stem cells

Keywords

• Bosma arhinia microphthalmia syndrome
• BAMS
• genetic disorder
• induced pluripotent stem cells
• cranial placode cells
• nasal epithelium
• developmental biology

Mentioned in this episode

Organizations: ISSCR

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