Episode 144: [The LOdown] Low Pregnenolone vs DHEA-S: The Hormones Before the Hormones

Episode 144: [The LOdown] Low Pregnenolone vs DHEA-S: The Hormones Before the Hormones

May 6, 2026 · 30 min · Episode 90

About this episode

This episode explores the roles of pregnenolone and DHEA-S in women's health and their impact on hormone balance.

Low Pregnenolone vs DHEA-S: The Hormones Before the Hormones In this episode, we’re diving into two of the most overlooked hormones in women’s health: pregnenolone and DHEA-S — the hormones before the hormones. While estrogen, progesterone, and testosterone often get the spotlight, pregnenolone and DHEA play a foundational role in the hormone cascade and can significantly influence energy, metabolism, fertility, cycles, thyroid function and stress resilience. When these hormones become depleted or dysregulated, symptoms like fatigue, cycle irregularities, low libido, poor recovery, inflammation, brain fog, and hormone imbalances can follow. A few things we chat about in this episode 👇👇👇 What pregnenolone & DHEA do in your hormone cascade Why they sit at the root of estrogen, progesterone, and testosterone balance What low pregnenolone or DHEA can mean, even with “normal” labs How bottlenecks between pregnenolone & DHEA disrupt hormone balance How stress shifts pregnenolone into downstream hormone pathways How low DHEA impacts ovulation, cycles, and hormones The link between energy, mitochondria, and pregnenolone and DHEA production Why these hormones are often…

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