
Why Your Brain Needs You to Run with Evolutionary Biologist David Raichlen
From The Trailhead by UltraSignup
April 28, 2026 · 56 min
About this episode
David Raichlen discusses the connection between running, brain health, and human evolution.
David Raichlen is a professor of biological sciences at the University of Southern California whose research examines how human evolution, physical activity, and brain health are linked across the lifespan. In this conversation, Zoë and Brendan talk with David about what's actually happening in your brain when you go from couch to consistently active, why exercise might be the closest thing we have to a dementia preventative, and why his research on the runner's high, which famously involved humans, dogs, and ferrets, suggests it evolved as something more useful than feeling good. They also get into what hunter-gatherers like the Hadza can (and can't) tell us about how to live, why "more is better" hits diminishing returns at the high end, the trouble with paleo prescriptions, and whether sitting really is the new smoking. Plus: Brendan tries to figure out if his rock-climbing mom or his golfing dad is doing better cognitive work than he is. This episode is brought to you by Running Warehouse, the one-stop shop for all things trail running, with gear guides and expert resources to help you figure out what actually works for you. Use code TRAILHEAD for free two-day shipping on…
People in this episode
Hosts: Zoë, Brendan
Guest: David Raichlen
Topics covered
- brain health
- exercise
- human evolution
- dementia prevention
- runner's high
- hunter-gatherers
- cognitive work
Keywords
- exercise
- brain health
- dementia
- runner's high
- hunter-gatherers
- cognitive function
- physical activity
Sponsors
Running Warehouse
Mentioned in this episode
Organizations: University of Southern California
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