About this episode

This episode discusses leptin resistance and its impact on weight loss and metabolism in midlife women.

Leptin resistance, weight loss resistance, metabolism, and hormone signaling in midlife women. If you’ve been doing everything right — eating well, exercising, staying consistent — and your body still isn’t responding, this can feel incredibly frustrating. In this episode, Janell breaks down leptin resistance, a metabolic signaling pattern that often sits underneath stubborn weight, low energy, and hormone disruption. Leptin is a hormone that helps your brain understand how much energy your body has available. When that signal is clear, your body can regulate hunger, use energy efficiently, and maintain a stable metabolism. But when leptin signaling is disrupted, your body can shift into protection mode — holding on to weight even when your habits look supportive. This episode explores how leptin connects with cortisol, insulin, thyroid function, and the nervous system, and why restriction and overtraining can sometimes reinforce the very pattern you’re trying to change. You’ll learn why this is not a willpower issue, and how your body’s response is often rooted in safety, not failure. In This Episode You’ll Learn • Why weight resistance is often a signaling issue, not a…

People in this episode

Host: Janell Yule

Topics covered

• leptin resistance
• weight loss resistance
• metabolism
• hormone signaling
• midlife women
• energy regulation

Keywords

• leptin resistance
• weight loss
• metabolism
• hormone disruption
• energy regulation
• cortisol
• insulin
• thyroid function

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