TWiN 71: Psychedelics rewire the brain from within
From This Week in Neuroscience by Vincent Racaniello
April 29, 2026 · 1h 31m · Episode 70
About this episode
The episode discusses how activation of intracellular serotonin 2A receptors contributes to the effects of psychedelics on brain plasticity and antidepressant-like properties.
TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds. Hosts: Vincent Racaniello , Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts , Google Podcasts , RSS Links for this episode MicrobeTV Discord Server Psychedelics rewire the brain from within (Science) Psychedelics elicit their effects by Gi signaling (Nature) History of LSD (Wikipedia) Timestamps by Jolene Ramsey . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
People in this episode
Hosts: Vincent Racaniello, Vivianne Morrison, Tim Cheung
Topics covered
- psychedelics
- serotonin receptors
- brain plasticity
- antidepressant properties
- neuroscience
Keywords
- psychedelics
- serotonin 2A receptors
- brain plasticity
- antidepressant
- neuroscience
Mentioned in this episode
Organizations: MicrobeTV, Discord Server
Books & works: Psychedelics rewire the brain from within, Psychedelics elicit their effects by Gi signaling, History of LSD
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