About this episode

The episode discusses the potential misattribution of mortality benefits in COPD patients related to inhaled corticosteroid withdrawal.

Previous trials on triple therapy inhaler use (ETHOS and IMPACT) were understood to show a reduction in mortality in COPD patients. However, a reanalysis published in Thorax shows that this benefit may have been misattributed. Host Dr. Kate Diomede is joined by the paper's authors, pharmacist Kari Leung¹ and physician Prof. Aroon Hingorani², both members of the ​North Central London Joint Formulary committee. Read the paper: Inhaled corticosteroid withdrawal and mortality rate in trials of triple therapy inhalers for COPD Further reading: Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial 1. UCL Hospitals NHS Foundation Trust, London, UK2. University College London, London, UK Please engage in the conversation through the social media channels (Twitter - @ThoraxBMJ; Facebook - Thorax.BMJ) and subscribe on your preferred platform, to get the latest episodes directly on your device each month. We would love to hear your thoughts on the podcast, you can leave a review on Apple Podcasts or Spotify.

People in this episode

Host: Dr. Kate Diomede

Guests: Kari Leung, Prof. Aroon Hingorani

Topics covered

• COPD
• inhaled corticosteroids
• triple therapy
• mortality
• pharmacology

Keywords

• COPD
• inhaled corticosteroids
• triple therapy
• mortality
• Kari Leung
• Aroon Hingorani
• pharmacology
• clinical trials
• ETHOS
• IMPACT

Mentioned in this episode

Organizations: North Central London Joint Formulary committee, UCL Hospitals NHS Foundation Trust, University College London

Books & works: Inhaled corticosteroid withdrawal and mortality rate in trials of triple therapy inhalers for COPD, Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial

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