MOTS-C Peptide Explained: Mitochondrial Health, Metabolic Function, and Longevity Science
About this episode
This episode discusses the MOTS-c peptide and its implications for metabolic health and longevity.
In this episode, we deliver an in-depth, evidence-based discussion on the MOTS-c peptide , a mitochondria-derived peptide that has gained significant attention in metabolic health, insulin sensitivity, exercise performance, and longevity research. MOTS-c is unique among peptides because it is encoded by mitochondrial DNA and functions as a key regulator of cellular energy metabolism and stress adaptation. This podcast explores how MOTS-c works at the cellular level , its role in activating AMPK pathways, regulating glucose utilization, and supporting mitochondrial resilience. We examine preclinical and emerging human research on MOTS-c’s potential impact on metabolic syndrome, age-related decline, obesity, inflammation, and exercise capacity , while clearly distinguishing established science from ongoing investigation.
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