About this episode

The episode explores the evolving understanding of obesity, including its biological factors and emerging treatments.

As we kick off season six, we’re diving deeper into one of our most popular topics from last season – our evolving understanding of obesity. In this episode, co-host Maria Wilson unpacks the latest in obesity biology and management with Manu Chakravarthy, Senior Vice President and Global Head of Cardiovascular, Renal and Metabolism Product Development, who discusses the stigma associated with obesity and how thousands of years of human evolution contribute to this chronic condition. While lifestyle, diet and exercise modifications are still essential in addressing the biological factors that drive obesity, they explore how emerging treatments have the potential to rewire the brain’s hunger and satiety signals – offering a more personalized, sustainable approach. Read the full text transcript at www.gene.com/stories/digging-deeper-into-obesity

People in this episode

Host: Maria Wilson

Guest: Manu Chakravarthy

Topics covered

• obesity
• biology
• management
• stigma
• evolution
• treatment

Keywords

• hunger
• satiety
• personalized treatment
• chronic condition

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• S7E02: Breakthroughs in MS · April 14, 2026 · 39 min
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• Season Seven Teaser · March 3, 2026 · 3 min
• S6E07: Foundation Models and Agents · December 9, 2025 · 46 min
• S6E06: Decoding Lung Disease · October 21, 2025 · 40 min
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