Beyond EGFR: navigating molecular targets and emerging therapies in advanced NSCLC
From VJOncology Podcast by VJOncology
April 30, 2026 · 17 min · Episode 224
About this episode
This episode explores the evolving treatment landscape of advanced non-small cell lung cancer with insights from leading experts.
In this week's instalment of the VJOncology podcast, we examine the rapidly evolving treatment landscape of advanced non-small cell lung cancer, drawing on expert insights from ELCC 2026. This episode spans the breadth of precision oncology in NSCLC: from the clinical challenges of rare actionable alterations and emerging targeted agents, to the growing complexity of first-line treatment sequencing, and the arrival of a promising new immunotherapy class in thoracic oncology. Leading clinicians and researchers from the Jules Bordet Institute, Princess Margaret Cancer Centre, Institut Curie, and Lausanne University Hospital discuss BRAF non-V600E mutations, KRAS G12C, HER2-mutant disease, EGFR exon 20 insertions, amivantamab-based combinations, and the evolving role of bispecific T-cell engagers in NSCLC and mesothelioma. This episode provides actionable insight for clinicians navigating an increasingly crowded and competitive treatment landscape in advanced NSCLC.
Topics covered
- advanced non-small cell lung cancer
- precision oncology
- molecular targets
- emerging therapies
- treatment sequencing
- immunotherapy
Keywords
- NSCLC
- targeted agents
- clinical challenges
- treatment landscape
- immunotherapy
- precision oncology
- BRAF mutations
- KRAS
- EGFR
Mentioned in this episode
Organizations: Jules Bordet Institute, Princess Margaret Cancer Centre, Institut Curie, Lausanne University Hospital
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