Bispecifics ate CAR-T's lunch: a multiple myeloma debate

About this episode

The episode features a debate on the treatment options for first relapse in multiple myeloma, focusing on CAR-T and bispecific therapies.

In this episode, Bernie and Anthony are joined by Myeloma Man Manni Mohyuddin, MD to discuss the debate surrounding the treatment of first relapse in multiple myeloma. Should we be using CAR-T? Bispecifics? How does the new mezigdomide data from ASCO 2026 inform our practice? Listen in for a spicy discussion! Articles discussed: Nature Reviews Commentary: https://www.nature.com/articles/s41571-026-01159-6 CARTITUDE-4: https://www.nature.com/articles/s41571-026-01159-6 MajesTEC-3: https://www.nejm.org/doi/full/10.1056/NEJMoa2514663 MajesTEC-9: https://www.nejm.org/doi/abs/10.1056/NEJMoa2603870 Control arms in multiple myeloma trials: https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2026020329/567836/Improving-Control-Arms-in-2026-U-S-Myeloma-Trials Predictors for CAR T cell therapy-associated immune-related adverse events? https://pubmed.ncbi.nlm.nih.gov/41540109/ Dex prophylaxis for lymphocytosis: https://ashpublications.org/bloodadvances/article/10/10/3629/567462/Dexamethasone-prophylaxis-for-excessive-lymphocyte Mezi-KD vs. KD ASCO 2026: https://ascopubs.org/doi/10.1200/JCO.2026.44.17_suppl.LBA7506

People in this episode

Hosts: Bernie Marini, Anthony Perissinotti

Guest: Manni Mohyuddin, MD

Topics covered

• multiple myeloma
• CAR-T therapy
• bispecifics
• treatment debate
• ASCO 2026 data
• immune-related adverse events

Keywords

• multiple myeloma
• CAR-T
• bispecifics
• ASCO 2026
• mezigdomide
• treatment options
• immune-related adverse events

Mentioned in this episode

Books & works: Nature Reviews Commentary, CARTITUDE-4, MajesTEC-3, MajesTEC-9, Control arms in multiple myeloma trials, Predictors for CAR T cell therapy-associated immune-related adverse events?, Dex prophylaxis for lymphocytosis, Mezi-KD vs. KD ASCO 2026

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