372. Deprescribing Antidepressants

372. Deprescribing Antidepressants

From You Are Not Broken by Kelly Casperson, MD

May 24, 2026 · 47 min

About this episode

Kelly interviews Dr. Mark Horowitz about the long-term impacts of antidepressants and the challenges of deprescribing.

In this episode, Kelly interviews Dr. Mark Horowitz, a psychiatrist and author, about the long-term impacts of antidepressants, the challenges of coming off these medications, and the future of deprescribing. This conversation sheds light on why many people remain trapped on these drugs and what can be done to change this reality. Key Topics: The origins of Dr. Horowitz's involvement in deprescribing and his personal experience The widespread use of antidepressants in America and the long-term health risks How withdrawal symptoms can be mistaken for a need to stay on medication The insidious side effects of antidepressants, including weight gain, sexual dysfunction, and increased risk of fractures The lack of long-term studies and regulatory oversight on the effects of antidepressants The importance of informed consent and alternative treatment options How marketing and legal factors influence prescribing habits Strategies for safe tapering and support resources for deprescribing The evolving awareness and cultural shift regarding antidepressant risks Deprescribing book https://markhorowitz.org/ Listen to my Tedx Talk: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Why we need adult sex…

People in this episode

Host: Kelly Casperson

Guest: Dr. Mark Horowitz

Topics covered

  • deprescribing
  • antidepressants
  • mental health
  • withdrawal symptoms
  • informed consent
  • tapering strategies

Keywords

  • antidepressants
  • deprescribing
  • mental health
  • withdrawal symptoms
  • tapering
  • informed consent
  • side effects

Mentioned in this episode

Organizations: markhorowitz.org

More episodes of You Are Not Broken

Explore listener stats, chart rankings, contacts and more on the You Are Not Broken podcast page.