Small Vessels, Big Trouble: How Vascular Disease Drives Dementia

Small Vessels, Big Trouble: How Vascular Disease Drives Dementia

April 20, 2026 · 57 min · Episode 161

About this episode

This episode explores vascular dementia, its causes, and its relationship with Alzheimer's disease, along with risk factors and preventative measures.

In this 161st episode I unpack vascular dementia — what causes it, how it differs from (and often overlaps with) Alzheimer’s, and the brain and vascular mechanisms that drive cognitive decline. I review some common clinical features of vascular dementia, noteworthy MRI findings, and the major vascular and metabolic risk factors involved in the development and progression of this disease. This is a great example of how a preventative approach nowcan save a lot of trouble later! Citations: Homocysteine and vascular disease https://pubmed.ncbi.nlm.nih.gov/8597939/ Trimethylamine N -Oxide: The Good, the Bad andthe Unknown https://pmc.ncbi.nlm.nih.gov/articles/PMC5127123/

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