About this episode

The episode discusses recent research on GFAP variants in relation to oxidative stress and lysosomal function in Alexander disease.

Send us Fan Mail Albee Messing, Dolores Pérez-Sala, and Natasha Snider discuss the following recent publications: Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants. Redox Biology 92:104103 (2026) Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander dise...

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