Alexander Disease Research Update
by Albee Messing
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On the show
From 12 epsHost
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Recent episodes
Alexander Disease Research Update – Episode #33: Can Initial MRI and Two Motor Milestones Predict Trajectory of Disease?
Jul 14, 2026
24m 46s
Alexander Disease Research Update – Episode #32: 1) GFAP variants and oxidative stress, and 2) GFAP variants and lysosomes
May 15, 2026
32m 18s
Alexander Disease Research Update – Episode #31: 1) Development of an AxD Severity Score, and 2) Peer review – please come home
Apr 1, 2026
22m 15s
Alexander Disease Research Update – Episode #30: 1) Speech-language impairments, and 2) GFAP concentrations in CSF and blood
Feb 1, 2026
28m 41s
Alexander Disease Research Update - Episode #29: Genotype-phenotype correlations, or does variant predict course?
Jan 20, 2026
14m 12s
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| Date | Episode | Topics | Guests | Brands | Places | Keywords | Sponsor | Length | |
|---|---|---|---|---|---|---|---|---|---|
| 7/14/26 | Alexander DiseaseMRI+3 | Ylenia Vaia | University of Wisconsin-MadisonNeuroradiological patterns and prognostic implications in type I Alexander disease+1 | — | Alexander DiseaseMRI+3 | — | 24m 46s | ||
| 5/15/26 | Alexander diseaseGFAP variants+4 | Dolores Pérez-SalaNatasha Snider | Redox BiologyAlexander disease+1 | — | GFAP variantsoxidative stress+4 | — | 32m 18s | ||
| 4/1/26 | Alexander DiseaseAxD Severity Score+4 | Annette BleyNadia Kokaly | Description of the Hamburg Alexander Leukodystrophy Cohort-Insights into Practical Classification and the Care SituationJournal of Clinical Medicine 14, 6918 (2025) | — | Alexander DiseaseAxD Severity Score+5 | — | 22m 15s | ||
| 2/1/26 | Alexander Diseasespeech-language impairments+3 | Debra LevinAmy Waldman | American Journal of Speech-Language PathologyAnnals of Clinical and Translational Neurology+2 | — | Alexander Diseasespeech-language pathology+5 | — | 28m 41s | ||
| 1/20/26 | genotype-phenotype correlationsAlexander disease+3 | Amanda Nagy | Molecular Genetics & Metabolism | — | Alexander diseasegenotype-phenotype correlations+3 | — | 14m 12s | ||
| 11/11/25 | Alexander DiseaseGDF15+5 | Tracy HagemannAbby Olsen | University of Wisconsin-MadisonGrowth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease Annals of Clinical and Translational Neurology | — | Alexander DiseaseGDF15+5 | — | 26m 29s | ||
| 7/9/25 | Alexander DiseaseGFAP variants+3 | Mel FeanyNatasha Snider | University of Wisconsin-Madison's Waisman CenterNeurology: Genetics+1 | — | Alexander DiseaseGFAP variants+3 | — | 32m 15s | ||
| 4/4/25 | gene expressioncognitive function+4 | Tracy HagemannRob Berman | University of Wisconsin-MadisonGFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease | — | Alexander diseasegene expression+5 | — | 28m 56s | ||
| 1/22/25 | Alexander DiseaseGFAP variants+5 | Charlie WadeMel Feany | UK BiobankUniversity of Wisconsin-Madison+2 | — | Alexander DiseaseGFAP variants+5 | — | 27m 21s | ||
| 11/25/24 | Alexander diseaseiPS cell model+4 | Natasha Snider | Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease GliaA novel GFAP frameshift variant identified in a family with optico-retinal dysplasia and vision impairment Human Molecular Genetics | — | Alexander diseaseiPS cells+4 | — | 28m 32s | ||
| 8/7/24 | Alexander Diseaseresearch update+3 | — | University of Wisconsin-Madison | Philadelphia | Alexander Diseaseresearch+3 | — | 22m 22s | ||
| 7/7/24 | anesthesiaAlexander disease+4 | Amy WaldmanNatasha Snider | Paediatric Anesthesia | — | Alexander diseaseanesthesia+5 | — | 20m 46s |
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