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From 11 epsHost
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Alexander Disease Research Update – Episode #32: 1) GFAP variants and oxidative stress, and 2) GFAP variants and lysosomes
May 15, 2026
32m 18s
Alexander Disease Research Update – Episode #31: 1) Development of an AxD Severity Score, and 2) Peer review – please come home
Apr 1, 2026
22m 15s
Alexander Disease Research Update – Episode #30: 1) Speech-language impairments, and 2) GFAP concentrations in CSF and blood
Feb 1, 2026
28m 41s
Alexander Disease Research Update - Episode #29: Genotype-phenotype correlations, or does variant predict course?
Jan 20, 2026
14m 12s
Alexander Disease Research Update - Episode #28: GDF15, nausea, vomiting, and "failure to thrive"
Nov 11, 2025
26m 29s
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| Date | Episode | Topics | Guests | Brands | Places | Keywords | Sponsor | Length | |
|---|---|---|---|---|---|---|---|---|---|
| 5/15/26 | Alexander Disease Research Update – Episode #32: 1) GFAP variants and oxidative stress, and 2) GFAP variants and lysosomes✨ | Alexander diseaseGFAP variants+4 | Dolores Pérez-SalaNatasha Snider | Redox BiologyAlexander disease+1 | — | GFAP variantsoxidative stress+4 | — | 32m 18s | |
| 4/1/26 | Alexander Disease Research Update – Episode #31: 1) Development of an AxD Severity Score, and 2) Peer review – please come home✨ | Alexander DiseaseAxD Severity Score+4 | Annette BleyNadia Kokaly | Description of the Hamburg Alexander Leukodystrophy Cohort-Insights into Practical Classification and the Care SituationJournal of Clinical Medicine 14, 6918 (2025) | — | Alexander DiseaseAxD Severity Score+5 | — | 22m 15s | |
| 2/1/26 | Alexander Disease Research Update – Episode #30: 1) Speech-language impairments, and 2) GFAP concentrations in CSF and blood✨ | Alexander Diseasespeech-language impairments+3 | Debra LevinAmy Waldman | American Journal of Speech-Language PathologyAnnals of Clinical and Translational Neurology+2 | — | Alexander Diseasespeech-language pathology+5 | — | 28m 41s | |
| 1/20/26 | Alexander Disease Research Update - Episode #29: Genotype-phenotype correlations, or does variant predict course?✨ | genotype-phenotype correlationsAlexander disease+3 | Amanda Nagy | Molecular Genetics & Metabolism | — | Alexander diseasegenotype-phenotype correlations+3 | — | 14m 12s | |
| 11/11/25 | Alexander Disease Research Update - Episode #28: GDF15, nausea, vomiting, and "failure to thrive"✨ | Alexander DiseaseGDF15+5 | Tracy HagemannAbby Olsen | University of Wisconsin-MadisonGrowth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease Annals of Clinical and Translational Neurology | — | Alexander DiseaseGDF15+5 | — | 26m 29s | |
| 7/9/25 | Alexander Disease Research Update – Episode #27: Genotype-phenotype association for 14 GFAP variants✨ | Alexander DiseaseGFAP variants+3 | Mel FeanyNatasha Snider | University of Wisconsin-Madison's Waisman CenterNeurology: Genetics+1 | — | Alexander DiseaseGFAP variants+3 | — | 32m 15s | |
| 4/4/25 | Alexander Disease Research Update – Episode #26: Changes in gene expression and cognitive function in the rat model✨ | gene expressioncognitive function+4 | Tracy HagemannRob Berman | University of Wisconsin-MadisonGFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease | — | Alexander diseasegene expression+5 | — | 28m 56s | |
| 1/22/25 | Alexander Disease Research Update – Episode #25: GFAP Variants in the UK Biobank - estimated prevalence of adult-onset AxD✨ | Alexander DiseaseGFAP variants+5 | Charlie WadeMel Feany | UK BiobankUniversity of Wisconsin-Madison+2 | — | Alexander DiseaseGFAP variants+5 | — | 27m 21s | |
| 11/25/24 | Alexander Disease Research Update – Episode #24: 1) iPS cell model with aberrant development and 2) unusual variant in GFAP affecting the eye✨ | Alexander diseaseiPS cell model+4 | Natasha Snider | Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease GliaA novel GFAP frameshift variant identified in a family with optico-retinal dysplasia and vision impairment Human Molecular Genetics | — | Alexander diseaseiPS cells+4 | — | 28m 32s | |
| 8/7/24 | Alexander Disease Research Update - Episode #23: Albee Messing's presentation at the recent conference in Philadelphia✨ | Alexander Diseaseresearch update+3 | — | University of Wisconsin-Madison | Philadelphia | Alexander Diseaseresearch+3 | — | 22m 22s | |
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| 7/7/24 | Alexander Disease Research Update - Episode #22: 1) anesthesia and AxD, and 2) GFAP cross-linking to itself✨ | anesthesiaAlexander disease+4 | Amy WaldmanNatasha Snider | Paediatric Anesthesia | — | Alexander diseaseanesthesia+5 | — | 20m 46s | |
| 5/16/24 | Alexander Disease Research Update - Episode #21: 1) Blood levels of GFAP, neurofilaments, and tau, and 2) planning for in-person conference in Philadelphia this summer. | Send us Fan Mail Albee Messing, Jenny Pearson, Natasha Snider, and Amy Waldman discuss the following recent publication and the conference planned for this summer in Philadelphia: [02:02] Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease Neurological Sciences (2024) [full text] [04:16] Discussion about Philadelphia Conference, August 2-4, ... | 15m 21s | ||||||
| 3/24/24 | Alexander Disease Research Update - Episode #20: 3D bioprinting method for co-culture of neurons and astrocytes reveals new features of Alexander disease | Send us Fan Mail Albee Messing and Linghai Kong discuss the following recent publication: [01:52] 3D bioprinting of human neural tissues with functional connectivity. Cell Stem Cell 31:260-274.e7 (2024) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: https://alexander-disease.waisman.wisc.edu/donat... | 15m 37s | ||||||
| 2/10/24 | Alexander Disease Research Update - Episode #19: Giant Axonal Neuropathy and Alexander Disease | Send us Fan Mail Albee Messing, Rachel Battaglia, and Natasha Snider discuss the following publication: [00:59] Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN) Molecular Biology of the Cell (in press) [full text - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846626/] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at th... | 18m 24s | ||||||
| 11/22/23 | Alexander Disease Research Update - Episode #18: 1) Quantitative MRI in rat model, and 2) Developmental milestones in cerebral form of AxD | Send us Fan Mail Albee Messing, Nick Stowe, JP Yu, and Amy Waldman discuss the following recent publications: [4:30] Stowe NA, Singh AP, Barnett BR, Yi SY, Frautschi PC, Messing A, et al. Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease. Magnetic Resonance in Medicine (2023) in press [15:11] Acquisition and Loss of Developmental Milestones and Time to Disease-Related Outcome... | 28m 42s | ||||||
| 9/8/23 | Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation | Send us Fan Mail Albee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications: [01:45] A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells Stem Cell Reports 18, 1701-1720 (2023) [includes new iPS cell line from an individual with Alexander disease] [full text] [05:39] Isolation of Intermediate F... | 24m 11s | ||||||
| 8/8/23 | Alexander Disease Research Update - Episode #16: Webinar - Guangping Gao lab | Send us Fan Mail Webinar on the strategy and preliminary results for “AAV-mediated Gene Silencing for the Treatment of Alexander Disease” presented by Drs. Guangping Gao, Jun Xie, and Dominic Gessler from the University of Massachusetts Medical School. This version is audio only - the full video version will be made available later at a site that is not yet determined. | 1h 08m 57s | ||||||
| 4/5/23 | Alexander Disease Research Update - Episode #15: subclassifications of Type I; questions regarding 1) mesenchymal stem cells and 2) the intransasal route of delivery | Send us Fan Mail Albee Messing and Davide Tonduti discuss the following recent publication: [00:41] Type I Alexander Disease: Update and Validation of the Clinical Evolution-Based Classification Molecular Genetics and Metabolism 138, 107540, 2023 [16:01] Questions from email regarding mesenchymal stem cells for transplantation and the intranasal route for delivering therapeutics to the central nervous system. Send your ques... | 20m 25s | ||||||
| 11/12/22 | Alexander Disease Research Update - Episode #14: whole exome/genome sequencing; more questions on the brainstem | Send us Fan Mail Albee Messing and Josh Bonkowsky discuss the following recent publication: [02:13] Identification of a novel de novo pathogenic variant in GFAP in an Iranian family with Alexander disease by whole-exome sequencing.European Journal of Medical Research 27, 174 (2022) [full text] [14:20] Questions from email regarding the brainstem in Alexander disease. Send your questions and feedback to: axdrupodcast@waisman... | 18m 17s | ||||||
| 10/13/22 | Alexander Disease Research Update - Episode #13: MRI diffusion tractography - what can it tell us? | Send us Fan Mail Albee Messing, Emi Takahashi, Arastoo Vossough, and Amy Waldman discuss the following recent publication: [02:03] Identification of association fibers using ex vivo diffusion tractography in Alexander disease brains Journal of Neuroimaging (in press) Send your questions and feedback to: axdrupodcast@waisman.wisc.edu | 16m 35s | ||||||
| 9/1/22 | Alexander Disease Research Update - Episode #12: GFAP variants and oxidative stress/mitochondrial dysfunction; commentary on dizziness, risks of brain biopsies | Send us Fan Mail Albee Messing, Rachel Battaglia, and Abby Olsen discuss the following recent publication: [01:00] Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress (Redox Biology, 55:102415, 2022) [14:23] Questions from email regarding 1) dizziness and 2) risks of brain biopsies. Send your questions and feedback to: axdrupodcast@wa... | 25m 25s | ||||||
| 8/5/22 | Alexander Disease Research Update - Episode #11: neurology 101 (location, location, location), discussion on the autonomic nervous system | Send us Fan Mail Albee Messing and Abby Olsen discuss the following recent publication: [03:04] Adult-onset Alexander disease: new causal sequence variant in the GFAP gene. (Neurology: Genetics, in press) [14:15] Autonomic nervous system – part 1 [26:09] Questions from email regarding connecting spinal cord problems and symptoms. [31:17] Autonomic nervous system – pa... | 33m 45s | ||||||
| 6/9/22 | Alexander Disease Research Update - Episode #10: effects of variants in the rod domain on GFAP assembly and aggregation, new ideas about functions of intermediate filaments | Send us Fan Mail Albee Messing and Natasha Snider discuss the following recent publication: [04:44] Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments (Molecular Biology of the Cell, in press) [28:53] Questions from email regarding heritability, penetrance, and skipping generations. Send your questions and feedback to: axdrupodcast@waisman.wisc.edu Help support ... | 34m 04s | ||||||
| 4/12/22 | Alexander Disease Research Update - Episode #9: new mechanisms of astrocyte dysfunction, case report with novel variant, commentary on head trauma as an aggravating factor | Send us Fan Mail Albee Messing, Mel Feany, Florian Eichler, and Ming der Perng discuss the following recent publications: [02:21] Wang L et al. (2022) Anastasis drives senescence and non-cell autonomous neurodegeneration in the astrogliopathy Alexander disease. Journal of Neuroscience (in press) [reports interesting new mechanisms of astrocyte dysfunction] [18:42] Kang YR et al. (2022). A novel in-frame GFAP p.E138_... | 41m 27s | ||||||
| 3/6/22 | Alexander Disease Research Update - Episode #8 - two case reports, natural history study of 21 pediatric patients, management of constipation | Send us Fan Mail Albee Messing and Amy Waldman discuss the following recent publications: [01:08] Mateos et al. (2022). Developmental delay and progressive seizures in 2-month-old child with diffuse MRI abnormalities. Brain Pathology e13049 [06:21] Takeuchi et al. (2022) GFAP variant p. Tyr366Cys demonstrated widespread brain cavitation in neonatal Alexander disease. Radiology Case Reports 17, 771-774 [full text] [13:48]&nb... | 23m 54s | ||||||
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