Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
From All-In with Chamath, Jason, Sacks & Friedberg by All-In Podcast, LLC
March 26, 2026 · 38 min
About this episode
Bryan Johnson discusses his experience with 5-MeO-DMT and its implications for brain health and human optimization.
(0:00) David Friedberg intros Bryan Johnson (0:54) Why Bryan Johnson did 5-MeO-DMT (12:56) What brain scans actually show (18:36) Psychosis, bad trips, and life-altering decisions (26:23) The next frontier: organoids and gene therapy (33:26) GLP-1s, abundance, and human optimization (35:35) The longevity drug nobody's talking about? Thanks to our partner for making this happen! The Pod by Eight Sleep cools your bed to 55°F and uses Autopilot to optimize your sleep, all night. Use code ALLIN at https://www.eightsleep.com/allin for up to $350 off. Follow Bryan: https://x.com/bryan_johnson https://www.youtube.com/BryanJohnson Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect
People in this episode
Host: David Friedberg
Guest: Bryan Johnson
Topics covered
- DMT
- brain scans
- psychosis
- gene therapy
- human optimization
- longevity
Keywords
- DMT
- 5-MeO-DMT
- brain scans
- psychosis
- gene therapy
- human optimization
- longevity drug
Sponsors
Eight Sleep
Mentioned in this episode
Organizations: The All-In Podcast
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