Circulating Tumor DNA Testing in Solid Tumors and Lymphoma Guideline
About this episode
Drs. Tina Lockwood and Stacy Gray discuss the ASCO guideline on circulating tumor DNA testing in solid tumors and lymphoma.
Drs. Tina Lockwood and Stacy Gray share the newly released evidence-based guideline on circulating tumor DNA (ctDNA) testing from ASCO. They highlight recommendations on when ctDNA testing should be offered—including scenarios where tissue biopsies are challenging, unsafe, or unavailable in time to guide management—and explicitly outline situations where testing should not be utilized. They dive into the evidence evaluating ctDNA for treatment selection, molecular residual disease (MRD), and response monitoring across solid tumors and lymphoma. Drs. Lockwood and Gray explain the importance of balancing ctDNA's high specificity with its moderate sensitivity. They also touch on outstanding questions, including standardizing definitions for MRD, disease-specific applications, and the use of multi-cancer early detection (MCED) screening. Read the full guideline, "Circulating Tumor DNA Testing in Solid Tumors and Lymphoma: ASCO Guideline" at www.asco.org/molecular-testing-and-biomarkers-guidelines " LINK TO FULL TRANSCRIPT
People in this episode
Guests: Tina Lockwood, Stacy Gray
Topics covered
- circulating tumor DNA
- solid tumors
- lymphoma
- biopsy challenges
- treatment selection
- molecular residual disease
- response monitoring
Keywords
- ctDNA
- biopsy
- MRD
- treatment selection
- early detection
- guideline
- oncology
Mentioned in this episode
Organizations: American Society of Clinical Oncology
Books & works: Circulating Tumor DNA Testing in Solid Tumors and Lymphoma: ASCO Guideline
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