About this episode

Dr. Lyudmila Bazhenova discusses the update to the living guideline on stage IV NSCLC without driver alterations, including evidence from recent trials and implications for treatment.

Dr. Lyudmila Bazhenova joins the podcast to share the update to the living guideline on stage IV NSCLC without driver alterations. Dr. Bazhenova discusses the evidence reviewed for both non-squamous NSCLC, including the POD1IM-304 and BAP BRAIN trials, and squamous cell NSCLC, including the HARMONi-6 trial. She shares how these results impacted the clinical practice guideline, what they mean for patients receiving immunotherapy and chemotherapy, and where the panel is waiting for additional evidence to clarify the role of therapeutic options. Dr. Bazhenova encourages listeners to stay tuned for future updates to the living guideline after publication of data from the 2026 ASCO Annual Meeting. Read the full living guideline " Therapy for Stage IV Non-Small Cell Lung Cancer without Driver Alterations, ASCO Living Guideline Version 2026.3.1 " LINK TO FULL TRANSCRIPT

People in this episode

Guest: Dr. Lyudmila Bazhenova

Topics covered

• Stage IV NSCLC
• Living guideline update
• Immunotherapy
• Chemotherapy
• Clinical practice guideline
• Non-squamous NSCLC
• Squamous cell NSCLC

Keywords

• NSCLC
• driver alterations
• living guideline
• immunotherapy
• chemotherapy
• clinical practice
• POD1IM-304
• BAP BRAIN
• HARMONi-6

Mentioned in this episode

Organizations: American Society of Clinical Oncology

Products: POD1IM-304, BAP BRAIN, HARMONi-6

Books & works: Therapy for Stage IV Non-Small Cell Lung Cancer without Driver Alterations, ASCO Living Guideline Version 2026.3.1

More episodes of ASCO Guidelines

• Treatment of Multiple Myeloma: ASCO Living Guideline Update 2026.1.1 · June 29, 2026 · 18 min
• Circulating Tumor DNA Testing in Solid Tumors and Lymphoma Guideline · June 18, 2026 · 18 min
• Therapy for Stage IV NSCLC With Driver Alterations: ASCO Living Guideline Update 2026.3.1 Part 2 · May 26, 2026 · 19 min

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