
Startup Success Starts with the Problem, Not the Tech with Marc Filerman
From AUTM on the Air by AUTM
April 15, 2026 · 53 min
About this episode
Marc Filerman discusses the importance of problem framing and value propositions in startup success.
Turning research into something that actually works in the real world sounds straightforward, but it rarely is. There’s a gap between discovery and impact that trips up even the most promising ideas, and it often has less to do with the science and more to do with how the problem is framed, understood, and communicated. My guest today is Marc Filerman, Chief Business Officer at Start2 Group, a global accelerator working across academia, startups, and government to help early-stage ventures de-risk, grow, and scale. Marc brings a unique perspective shaped by his background as an MIT-trained engineer, corporate leader, and serial startup founder. At Start2 Group, he helps run major programs like BARDA-supported VITAL and NSF-backed Stride Ventures, supporting thousands of companies and contributing to billions in follow-on funding. We talk about what actually separates startups that move forward from those that stall out, including the importance of defining a clear problem, building a real value proposition, and choosing a focused foothold market instead of trying to do everything at once. We also get into where universities and tech transfer offices have an opportunity to better…
People in this episode
Guest: Marc Filerman
Topics covered
- startup success
- problem framing
- value proposition
- tech transfer
- early-stage ventures
Keywords
- research
- impact
- entrepreneurship
- funding pathways
- commercialization
Mentioned in this episode
Products: Start2 Group, BARDA-supported VITAL, NSF-backed Stride Ventures
More episodes of AUTM on the Air
- How Novartis Approaches External Research Collaboration with Dr. Yogesh Sharma · June 10, 2026 · 27 min
- Bridging the Early-Stage Funding Gap in Innovation with Teri Willey · June 3, 2026 · 29 min
- Detecting Alzheimer’s Earlier with a Simple Blood Test with Yuanbing Jiang · May 27, 2026 · 23 min
- Turning Research into Real World Impact from the Inside Out with Ravini Moodley · May 20, 2026 · 24 min
- Timing, Trust, and Technical Credibility Building, the Long Game with Ram Krishnan · May 13, 2026 · 30 min
- The Missing Link Between Research and Real-World Impact with Ben Reinhardt · May 6, 2026 · 36 min
Explore listener stats, chart rankings, contacts and more on the AUTM on the Air podcast page.