About this episode

The episode discusses the potential link between creatine and shin pain, the effects of splitting training sessions, and considerations for lifters with endometriosis.

This is the free preview of the May 2026 Direct Line, our monthly AMA for Barbell Medicine Plus subscribers. Three reader questions answered in full. We open with a mid-30s woman with bilateral shin pain and exertional foot numbness who started creatine a month ago and is asking whether the supplement is the cause. We walk through the compartment syndrome literature, the 2025 case report being passed around online and misinterpreted, what creatine actually does to total body water (and what it doesn’t), the four compartment pressure studies that exist, the Waterman 2013 demographic data on who actually gets chronic exertional compartment syndrome, and the workup we would actually run if this person walked into clinic. Next, whether splitting your resistance training across the day affects strength and hypertrophy. We cover BBM’s general heuristic on frequency as a distribution tool for training load, the Schoenfeld meta-analyses on frequency (2016 and 2019), the wrinkle on cardiorespiratory fitness and exercise snacks, and where we go off the reservation compared to a strict evidence-based read. We close with endometriosis for the lifter, including the seven-year average…

People in this episode

Host: Barbell Medicine

Topics covered

• creatine and shin pain
• resistance training frequency
• endometriosis for lifters

Keywords

• creatine
• shin pain
• compartment syndrome
• resistance training
• endometriosis
• exercise frequency
• anti-inflammatory diet

Mentioned in this episode

Organizations: ESHRE

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