373: Preventing Alzheimer’s: Muscle, Sleep, + Metabolic Health | Louisa Nicola

373: Preventing Alzheimer’s: Muscle, Sleep, + Metabolic Health | Louisa Nicola

From Be Well by Kelly Leveque by Kelly Leveque

February 18, 2026 · 1h 7m

About this episode

Kelly Leveque interviews neuroscientist Louisa Nicola about Alzheimer's risk and prevention strategies.

In this episode, I sit down with neuroscientist Louisa Nicola to unpack what women actually need to know about Alzheimer’s risk, cognitive decline, and long term brain protection. We break down APOE genetics, advanced blood biomarkers that can now detect amyloid and tau with remarkable accuracy, and why brain health is inseparable from metabolic health. Louisa explains how muscle acts as a metabolic sink for glucose, why resistance training and high intensity intervals stimulate BDNF, and how sleep drives the glymphatic system to clear amyloid from the brain. If you want practical tools to assess your personal risk, understand your labs, and build a proactive prevention plan decades before symptoms appear, this conversation is for you. → Leave Us A Voice Message! Topics Discussed: → What does APOE4 mean for Alzheimer’s risk? → Can exercise prevent cognitive decline? → Do blood tests detect early Alzheimer’s? → How does perimenopause affect brain health? → Does hormone therapy reduce dementia risk? Sponsored By: → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/KELLY and save up to 39% off your Mitopure® Gummies. → Be…

People in this episode

Host: Kelly

Guest: Louisa Nicola

Topics covered

  • Alzheimer’s risk
  • cognitive decline
  • brain protection
  • APOE genetics
  • blood biomarkers
  • metabolic health
  • muscle health
  • resistance training
  • high intensity intervals
  • sleep
  • glymphatic system
  • perimenopause
  • hormone therapy

Keywords

  • brain health
  • exercise
  • blood tests
  • dementia risk
  • personal risk assessment

Sponsors

Timeline, Be Well By Kelly, Cozy Earth

Mentioned in this episode

Products: Mitopure® Gummies, Cozy Earth, Be Well By Kelly Protein Powder & Essentials

Books & works: Be Well by Kelly

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