The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the Decline

About this episode

This episode explores the depletion of NAD+ in skin cells and its impact on aging, discussing the enzymes involved and the science behind replenishing it.

Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place. By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there. The enzyme your skin uses for DNA repair can wipe out up to 90% of what's left after a single afternoon in the sun. This isn't a slow, graceful decline. It's a collapse happening beneath the surface long before the wrinkles appear. In this episode, we will nerd out and break down exactly why NAD+ disappears, who the thieves are, and what the science actually says about getting it back. From the sirtuin-PARP-CD38 trifecta to the zombie cell feedback loop that accelerates the drain with age, this is the most complete picture of NAD+ and skin aging we've put together to date. We also cover the real differences between NMN, NR, and niacin, why the precursor you choose actually matters, and what to stack with it to protect your methylation pathways. Ready to nerd out in this with us? Let's dive in! What's Discussed: (4:00) The number that changes how you…

People in this episode

Host: Young Goose

Topics covered

• NAD+ depletion
• skin aging
• enzymes
• DNA repair
• supplements
• sirtuins
• cellular health

Keywords

• NAD+
• skin aging
• sirtuins
• PARP
• CD38
• NMN
• NR
• niacin
• DNA repair
• zombie cells

Mentioned in this episode

Organizations: sirtuin, PARP, CD38, NMN, NR, niacin

Products: NAD+

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