Emerging Mechanisms: Neutrophils and Immune thrombocytopenia from ICI

About this episode

This episode features an interview discussing new mechanisms related to neutrophils and immune thrombocytopenia in the context of immune checkpoint inhibitors.

In this week's episode of the Blood podcast, editor Dr. James Griffin interviews Drs. Christian Gorzelanny and Rebecca Leaf on their latest articles published in this week's issue of Blood . Dr. Gorzelanny discusses compelling evidence for a new mechanism that amplifies their proinflammatory actions in " Lipid nanotubes unmask neutrophils for complement attack ", demonstrating the pathological role of this process in a range of inflammatory disorders in order to stimulate intense study of how to regulate nanotube formation for therapeutic benefit. In " Immune thrombocytopenia in patients treated with immune checkpoint inhibitors " Dr. Leaf and colleagues define the incidence, clinical features, and outcomes of ICI-induced immune thrombocytopenia. Showing that ICI-induced immune thrombocytopenia is associated with excess mortality, these data should provide an impetus to greater recognition and to protocolization of effective interventions.

People in this episode

Host: Dr. James Griffin

Guests: Dr. Christian Gorzelanny, Dr. Rebecca Leaf

Topics covered

• neutrophils
• immune thrombocytopenia
• immune checkpoint inhibitors
• inflammatory disorders
• therapeutic interventions

Keywords

• neutrophils
• immune thrombocytopenia
• immune checkpoint inhibitors
• inflammatory disorders
• therapeutic benefit
• excess mortality
• clinical features

Mentioned in this episode

Organizations: Blood

Books & works: Lipid nanotubes unmask neutrophils for complement attack, Immune thrombocytopenia in patients treated with immune checkpoint inhibitors

More episodes of Blood Podcast

• Future Directions in Relapsed and Refractory Large B-cell Lymphoma · June 11, 2026 · 25 min
• Review Series on Clonal Tracking in Hematopoiesis · June 4, 2026 · 30 min
• New Approaches: Marstacimab Therapy and HLH Biomarkers · May 28, 2026 · 18 min
• Review Series on Hemophagocytic Lymphohistiocytosis (HLH) · May 21, 2026 · 16 min
• IBD augmentation of CHIP and Platelet mTOR's impact on Cerebral Malaria · May 14, 2026 · 21 min
• Long-term efficacy and safety of betibeglogene autotemcel for β-thalassemia · May 7, 2026 · 13 min