About this episode

This episode features an interview with Drs. Shengwen Calvin Li and Hrishi Krishna Srinagesh discussing their research on ANKRD26-related thrombocytopenia and B-cell ALL recurrence after blinatumomab.

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Shengwen Calvin Li and Hrishi Krishna Srinagesh on their latest articles published in Blood . Dr. Li discusses " Single-cell profiling of ANKRD26 thrombocytopenia reveals progenitor expansion and polyploid apoptosis via JUNB-p21 ". The study identifies reproducible abnormalities in progenitor expansion and increased apoptosis of polyploid megakaryocytes, and they propose a novel mechanism in which centrosomal over-expression of ANKRD26 drives polyploid megakaryocyte apoptosis through JUNB-mediated induction of p21 transcription. Dr. Srinagesh discusses " Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL " in which data collected by the Real-World Outcomes Collaborative of CAR-T in Adult ALL consortium showed that prior nonresponse to blinatumomab was associated with inferior survival after brexucabtagene in comparison to blinatumomab-naïve patients. Early CAR-T responses were uniformly high regardless of prior exposure or response. This highlights that resistance to blinatumomab may identify patients at higher risk of post–CAR T relapse despite excellent initial…

People in this episode

Host: Dr. Laurie Sehn

Guests: Dr. Shengwen Calvin Li, Dr. Hrishi Krishna Srinagesh

Topics covered

• ANKRD26-related thrombocytopenia
• B-cell ALL
• blinatumomab
• CAR-T therapy
• polyploid megakaryocytes
• apoptosis
• survival outcomes

Keywords

• ANKRD26
• thrombocytopenia
• B-cell ALL
• blinatumomab
• CAR-T
• apoptosis
• survival
• megakaryocytes
• JUNB
• p21

Mentioned in this episode

Organizations: American Society of Hematology

Books & works: Single-cell profiling of ANKRD26 thrombocytopenia reveals progenitor expansion and polyploid apoptosis via JUNB-p21, Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL

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