#124 – Dosing Consult: Cefepime

About this episode

The episode discusses the ideal dosing of cefepime, including adjustments for renal impairment and the role of therapeutic drug monitoring.

Drs. Erin Barreto (@erin_barreto) and Jeffrey Lipman join Dr. Whitney Buckel for a conversation on ideal dosing of cefepime. Hear from the experts on the differences between package insert and “high-dose” regimens, adjustments for renal impairment/augmented renal clearance, and the role of cefepime therapeutic drug monitoring. References: Barreto EF, et al. Setting the Beta-Lactam Therapeutic Range for Critically Ill Patients: Is There a Floor or Even a Ceiling? Crit Care Explor. 2021 Jun 11;3(6):e0446.PMID: https://pubmed.ncbi.nlm.nih.gov/34136822/ Barreto EF, et al. Adequacy of cefepime concentrations in the early phase of critical illness: A case for precision pharmacotherapy. Pharmacotherapy. 2023 Nov;43(11):1112-1120. https://pubmed.ncbi.nlm.nih.gov/36648390/ ** **Udy AA, et al. Augmented renal clearance: implications for antibacterial dosing in the critically ill. Clin Pharmacokinet. 2010;49(1):1-16. https://pubmed.ncbi.nlm.nih.gov/20000886/ Lipman J, Wallis SC, Boots RJ. Cefepime versus cefpirome: the importance of creatinine clearance. Anesth Analg. 2003 Oct;97(4):1149-1154. doi: 10.1213/01.ANE.0000077077.54084.B0.PMID: 14500173 Roberts JA, Ulldemolins M, Roberts MS…

People in this episode

Host: Dr. Whitney Buckel

Guests: Dr. Erin Barreto, Dr. Jeffrey Lipman

Topics covered

• cefepime dosing
• renal impairment
• therapeutic drug monitoring
• critical illness
• pharmacotherapy

Keywords

• cefepime
• dosing consult
• renal clearance
• therapeutic drug monitoring
• critical care

Mentioned in this episode

Books & works: Setting the Beta-Lactam Therapeutic Range for Critically Ill Patients: Is There a Floor or Even a Ceiling?, Adequacy of cefepime concentrations in the early phase of critical illness: A case for precision pharmacotherapy, Augmented renal clearance: implications for antibacterial dosing in the critically ill, Cefepime versus cefpirome: the importance of creatinine clearance, Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept

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