The 4-Hour Sleepers Redefining Human Limits with Ying-Hui Fu of UCSF

The 4-Hour Sleepers Redefining Human Limits with Ying-Hui Fu of UCSF

June 26, 2025 · 33 min · Season 1 · Episode 65

About this episode

The episode features an interview with Ying-Hui Fu discussing the genetics of sleep and how some individuals thrive on limited sleep.

Matias and Greg interview Ying-Hui Fu, PhD, is a Professor of Neurology at UCSF and a world leader in the genetics of sleep. Her lab has discovered the first-known genes behind “natural short sleepers”. Her work bridges human genetics and neuroscience to uncover how to modulate sleep for brain health, aging, and neurodegenerative diseases. In this episode, we discuss: How some people thrive on 4–6 hours of sleep with rare genetic mutationsWhy sleep efficiency is more important than total hour...

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