Transforming Skin Cells into Neurons to Treat Alzheimer’s with Brendon Boot of Skin2Neuron

Transforming Skin Cells into Neurons to Treat Alzheimer’s with Brendon Boot of Skin2Neuron

August 21, 2025 · 54 min · Season 1 · Episode 67

About this episode

The episode discusses innovative approaches to treating Alzheimer's by transforming skin cells into neurons with insights from neurologist Brendon Boot.

Greg and Matias interview Brendon Boot of Skin2Neuron. Brendon is a neurologist at Harvard and Mayo Clinic with prior experience as Medical Director at Biogen overseeing their Phase 1b Alzheimer’s trials. In this episode, we discuss: How skin-derived cells can be turned into neurons to repair the brain.Why replacing lost neurons may succeed where drugs have failed in Alzheimer’s.What makes autologous (self-derived) cell therapy safer and more effective.How testing in dogs brought stronger pro...

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