About this episode
Drs. Maria Pabon and Robert Mentz discuss the role of mineralocorticoid receptor antagonism in heart failure, focusing on patients at elevated biologic risk.
Faculty: Maria Pabon, MD Faculty: Robert J. Mentz, MD, FHFSA, FACC In this brief podcast, Drs. Maria Pabon and Robert Mentz explore the evolving role of mineralocorticoid receptor antagonism in heart failure, with emphasis on patients who appear clinically stable yet remain at elevated biologic risk. They contrast steroidal and nonsteroidal MRAs, highlighting differences in receptor selectivity, cardiac-renal distribution, and downstream anti-fibrotic and anti-inflammatory signaling. Faculty address the principle that symptom stability does not equate to disease stability, offering strategies to identify patients with HFpEF or HFmrEF who may benefit from a risk-based treatment approach.
People in this episode
Guests: Maria Pabon, MD, Robert J. Mentz, MD, FHFSA, FACC
Topics covered
- mineralocorticoid receptor antagonism
- heart failure
- risk-based treatment
- HFpEF
- HFmrEF
- anti-fibrotic signaling
- anti-inflammatory signaling
Keywords
- mineralocorticoid receptor antagonism
- heart failure
- HFpEF
- HFmrEF
- anti-fibrotic
- anti-inflammatory
- risk-based treatment
Mentioned in this episode
Organizations: ReachMD
More episodes of CME
- Counseling Patients on Their Future with Biologics · May 14, 2026 · 1 min
- Safety in oHCM Therapy: How and When to Transition Treatment? · May 2, 2026 · 11 min
- Optimizing Iron Deficiency Management in CKD: IV Iron Replacement Therapy Amid the Latest KDIGO Guidelines · April 30, 2026 · 12 min
- Enhancing Collaborative Care in Retinal Diseases: A Focus on Injection Therapies · April 10, 2026 · 58 min
- Transforming Care in Pediatric Patients With C3 Glomerulopathy: Targeting C3 at the Source · April 7, 2026 · 14 min
- Navigating Today and Shaping Tomorrow in ISM: Personalized Strategies With Current and Emerging KIT Inhibitors · March 31, 2026 · 14 min
Explore listener stats, chart rankings, contacts and more on the CME podcast page.