About this episode
This episode discusses the management of obstructive hypertrophic cardiomyopathy and the challenges in treatment options.
Faculty: Michael Nassif, MD, MSc This activity examines the evolving management of obstructive hypertrophic cardiomyopathy (oHCM), from persistent unmet needs to precision-based therapy with cardiac myosin inhibitors. Faculty review ongoing symptom burden and functional limitations despite guideline-directed first-line therapy with beta-blockers and analyze mechanistic, pharmacokinetic, and pharmacodynamic differences among available agents, including their effects on peak VO₂, left ventricular outflow tract gradients, and patient-reported outcomes. Through expert discussion and case-based application, the activity highlights practical considerations for treatment selection, individualized dosing and titration, safety monitoring, and treatment transitions to support evidence-based strategies that optimize hemodynamics and improve quality of life in patients with oHCM.
People in this episode
Guests: Michael Nassif, MD, MSc, Michael Nassif
Topics covered
- obstructive hypertrophic cardiomyopathy
- precision-based therapy
- treatment selection
- individualized dosing
- patient-reported outcomes
Keywords
- oHCM
- treatment
- cardiac myosin inhibitors
- beta-blockers
- patient outcomes
- hemodynamics
- quality of life
Mentioned in this episode
Organizations: ReachMD, cardiac myosin inhibitors, beta-blockers, oHCM
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