About this episode

The episode discusses five late-breaking trials presented at ESCMID Global 2026, focusing on their implications for clinical practice.

Our editors – Marc Bonten, Erin McCreary, Anne-Grete Märtson, Angela Huttner, and Josh Davis – are back for part two of the ESCMID Global Late Breakers series, summarising five more late-breaking trials presented at ESCMID Global 2026. They discuss the trials' strengths and weaknesses, and whether their results should change practice. The five trials presented in this half of the series are listed below, and links to their respective sessions can be watched and rewatched on the ESCMID Global Virtual Platform. Links to corresponding abstracts and publications where available are provided as well. Conflict of interest/involvement in the trials: Marc Bonten was the chair of the E.mbrace trial's steering committee Josh Davis is global co-lead of the SNAP trial Josh Davis was a site investigator on the E.mbrace trial Angela Huttner was an independent/unpaid member of the E.mbrace trial's steering committee and an investigator on the precursor phase 1 trial testing the E. coli vaccine PROCALBAN trial ( Late-breaking clinical trials in sepsis management ) Chowdhury F, et al. Use of Procalcitonin Point-Of-Care Testing to Guide De-Escalation of Antibiotic Therapy in Adult Sepsis Patients…

Topics covered

• sepsis management
• clinical trials
• antibiotic therapy
• healthcare practices
• medical research

Keywords

• sepsis
• clinical trials
• antibiotic therapy
• vancomycin
• E. coli vaccine

Mentioned in this episode

Organizations: ESCMID, The Lancet, E.mbrace, SNAP, PROCALBAN

Books & works: BENEFICIAL trial, Chowdhury F, et al., De Cock PA, et al.

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