About this episode

Professor Louise Serpell discusses the complexities of Alzheimer's disease and the factors influencing its understanding and research.

Professor Louise Serpell, narrates her blog written for the Dementia Researcher website. In this blog, Louise reflects on why Alzheimer’s disease has proved so difficult to understand, despite more than a century of research. She traces the role of amyloid beta, tau, inflammation, synaptic loss, genetics, ageing, the microbiome and other factors, while also asking what research models can and cannot capture. The blog argues that Alzheimer’s is shaped across a lifetime, by biology, environment, experience and individual variation, making collaboration across research fields essential for better prevention, diagnosis and treatment. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-alzheimers-disease-takes-a-lifetime/ -- Professor Louise Serpell is an Emerita Professor of Biochemistry at the University of Sussex. Her research focuses on how proteins misfold and form amyloid structures linked to Alzheimer’s disease and other neurodegenerative conditions, using approaches from structural biology and molecular biophysics. Louise completed her DPhil at the University of Oxford and later established her own research group in the UK…

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