13 Ways the Spike Protein Is Keeping You Sick with Evan H. Hirsch, MD

13 Ways the Spike Protein Is Keeping You Sick with Evan H. Hirsch, MD

May 27, 2026 · 17 min · Episode 216

About this episode

Evan H. Hirsch, MD discusses how the spike protein continues to affect health long after COVID infection, detailing 13 mechanisms that contribute to fatigue and other symptoms.

Your fatigue, brain fog, and lingering symptoms after COVID may not be random. The spike protein can keep disrupting your body long after the initial infection clears. Evan H. Hirsch, MD, breaks down 13 distinct mechanisms through which the spike protein continues affecting energy production, immune function, circulation, the gut, and nervous system regulation in people dealing with Long COVID, ME/CFS, and chronic fatigue. This episode also explains why so many people address symptoms one at a time and still plateau, and what the layer underneath the 13 mechanisms actually is. In this episode, you'll learn: Why the spike protein does not always leave when the infection clears How microclots block oxygen delivery even when labs look completely normal The biological explanation for post-exertional malaise and why pushing harder makes it worse Why 57% of Long COVID clients develop exercise-induced dysautonomia How gut disruption and serotonin depletion drive fatigue, brain fog, and mood changes What the Toxic 5 are and why they keep the 13 mechanisms running long after the acute illness is gone Discover your fatigue score and the root causes keeping you stuck…

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Host: Evan H. Hirsch, MD

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Organizations: EnergyMD, myfatiguescore.com, fixyourfatigue.com, energymdmethod.com

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