About this episode

The episode discusses Srinjan Basu's research on chromatin architecture and its role in developmental gene expression.

In this episode of the Epigenetics Podcast, we talked with Srinjan Basu from Imperial College London to talk about his work on how chromatin architecture and epigenetic mechanisms orchestrate developmental gene expression programs. We begin by exploring Dr. Basu's early work at Harvard which involved pioneering Raman-based label-free imaging, allowing the study of chromatin dynamics in live tissue. Here, he tackles technical challenges faced in visualizing DNA interactions, emphasizing the shift from 2D to 3D analysis and the importance of real-time observation of chromatin behavior under various conditions. This segues into his groundbreaking research on single transcription factors interacting with chromatin, revealing subtle but significant changes in the dynamics of gene regulation. We transition into the complexities of chromatin architecture as Dr. Basu recounts his efforts in mapping the entire mouse genome in single pluripotent cells, unearthing unexpected heterogeneity among cells. This heterogeneity raises intriguing questions about its impact on cellular function, prompting ongoing investigations into chromatin dynamics and the role of remodeling complexes like NuRD in…

People in this episode

Guest: Srinjan Basu

Topics covered

• chromatin dynamics
• gene regulation
• 3D genome organization
• cell fate
• epigenetic mechanisms

Keywords

• chromatin
• gene expression
• 3D analysis
• transcription factors
• cellular function
• epigenetics
• Raman imaging

Mentioned in this episode

Organizations: Imperial College London, Harvard, NuRD

Places: mouse genome

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