Polycomb and Three-Dimensional Genome Organisation (Oliver Bell)

About this episode

Oliver Bell discusses his research on chromatin-based regulatory systems and their implications for development and disease.

In this episode of the Epigenetics Podcast, we talked with Oliver Bell from the University of Southern California in Los Angeles about his work on chromatin-based regulatory systems that encode cellular memory and their implications for development and disease. The Interview starts with Dr. Bell describing his early career contributions to understanding the functionality of histone methylation in facilitating dosage compensation and gene silencing. His efforts at dissecting the complexities of epigenetic regulation culminate in significant discoveries that highlight the nuanced effects of chromatin adjustments on gene activity and stability across cell divisions. As we progress, Dr. Bell shares details about his postdoctoral research, where he engineered systems to study chromatin remodeling and the maintenance of transcriptional states through development. His innovative use of induced proximity to manipulate chromatin modifiers offers groundbreaking approaches to understanding how epigenetic states can be established and sustained, alongside the implications for therapeutic strategies in cancer treatment. An important aspect of our discussion centers on his identification of…

People in this episode

Guest: Oliver Bell

Topics covered

• chromatin regulation
• epigenetics
• gene silencing
• transcriptional states
• neurodevelopmental disorders
• cancer treatment

Keywords

• chromatin
• epigenetic regulation
• histone methylation
• gene activity
• transcriptional maintenance
• ZFP462
• neurodevelopment
• cancer therapy

Mentioned in this episode

Organizations: University of Southern California

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