Functional Forum Live from San Francisco

About this episode

The episode explores the modifiability of chronic diseases and cognitive decline through functional and precision medicine.

What if chronic disease, cognitive decline, and even trauma were not fixed conditions—but modifiable biological states? In this Functional Forum episode, James Maskell and Matt Wiggins bring together leading clinicians and researchers to explore the frontiers of precision and functional medicine. They discuss SUPAR, a powerful biomarker for systemic inflammation that could reshape early disease detection. The conversation then turns to a groundbreaking cognitive decline trial showing major improvements in patients treated with functional medicine protocols compared to standard care. The episode also explores the biology of loneliness and the "cell danger response," the reversibility of trauma through epigenetic mechanisms and psychedelic-assisted therapy, and emerging ideas about measuring masculinity as a clinical health indicator. Together, these insights point toward a future where chronic disease may be detected earlier, treated systemically, and in some cases reversed. - - - - - About the Guests: This episode features multiple leading voices from the Functional Forum community, including clinicians and researchers in functional and precision medicine: Matt Wiggins – Health…

People in this episode

Host: James Maskell

Guests: Matt Wiggins, Dr. Kat Toups, Dr. Molly Maloof

Topics covered

• chronic disease
• cognitive decline
• functional medicine
• precision medicine
• systemic inflammation
• epigenetic mechanisms
• psychedelic-assisted therapy

Keywords

• chronic disease
• cognitive decline
• functional medicine
• SUPAR
• systemic inflammation
• epigenetics
• psychedelics
• loneliness
• health indicators

Mentioned in this episode

Organizations: Functional Forum

Products: SUPAR

More episodes of Evolution of Medicine Podcast

• Mapping Qi Gong onto The Functional Medicine Matrix · June 8, 2026 · 31 min
• IFM AIC Recap - What You Missed · June 4, 2026 · 35 min
• Your Voice Builds Trust: How Doctors Win Patients Through Podcasting · May 20, 2026 · 26 min
• Resonance: The Art and Science of Human Connection · May 12, 2026 · 46 min
• Parsley Health: Now In Network Across 150m Lives · May 4, 2026 · 37 min
• Growbaby: Reducing Preterm Birth with Precision Nutrition · April 28, 2026 · 40 min