307. Dr. Sandra Kaufmann on Exosomes, Iron Toxicity, Mast Cells, Sirtuins, Bloodwork Misnomers, and the Longevity Supplements Nobody Talks About

307. Dr. Sandra Kaufmann on Exosomes, Iron Toxicity, Mast Cells, Sirtuins, Bloodwork Misnomers, and the Longevity Supplements Nobody Talks About

June 19, 2026 · 1h 7m · Episode 307

About this episode

Dr. Sandra Kaufmann returns to discuss various aspects of longevity, including exosomes, iron toxicity, and the importance of understanding bloodwork.

Dr. Sandra Kaufmann is back for round two. She's the creator of the Kaufmann Protocol, author of three books on the science of aging, and a longevity physician. In addition to her clinics in Miami and Las Vegas, she also runs Club Exosome, a quarterly gathering of longevity fanatics she calls a modern French salon. This is a conversation for anyone who wants to understand not just what to take, but also why and how to think about longevity at a level that actually moves the needle. — Episode Chapter Big Ideas (timing may not be exact) — 0:00 — Intro 2:49 — Club Exosome: what it is and why she calls it a French salon 3:29 — What she still believes from round one and what she's added 4:30 — Heterochromatin distribution: her new DNA obsession 5:30 — Why circadian rhythms are strictly biochemical 6:32 — Mast cells: why they increase with age and why that matters 7:48 — Iron toxicity: the silent accumulator nobody talks about 9:05 — Clean bloodwork but still at risk: how iron hides in your tissues 10:06 — The plague theory: why your ancestors' iron storage may be killing you slowly 12:09 — How to actually test for tissue iron accumulation 12:57 — Why giving iron to older patients with…

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