189. Dr. Florence Comite: The 5 Biomarkers That Predict How You'll Age

189. Dr. Florence Comite: The 5 Biomarkers That Predict How You'll Age

August 11, 2026 · 36 min

About this episode

Dr. Florence Comite discusses how precision medicine and specific biomarkers can predict and potentially reverse aging and chronic diseases.

What if aging isn't something you simply accept - but something you can measure, predict, and even reverse? Most of us are told our lab work is "normal," yet chronic disease often develops silently for years before symptoms appear. Dr. Florence Comite, one of the world's leading pioneers in precision medicine, is explaining why conventional medicine often misses the earliest signs of diesease- and how personalized data can completely change your health trajectory. Drawing from more than three decades of experience at Yale, the National Institutes of Health, and her own precision medicine practice, Dr. Comite shares how treating every patient as an "N-of-1" allows her to identify hidden risks years before they become heart disease, diabetes, osteoporosis, dementia, or hormonal decline. Together, they explore the biomarkers that matter most, the surprising role of insulin resistance in nearly every chronic illness, and why your genes are far less predictive than the choices you make every day. If you've ever wondered whether it's possible to stay stronger, sharper, and healthier as you age, this conversation offers a practical roadmap backed by decades of research and real-world…

People in this episode

Host: Darshan Shah, MD

Guest: Dr. Florence Comite

Mentioned in this episode

Organizations: Yale, National Institutes of Health

More episodes of Extend Podcast with Darshan Shah, MD

Explore listener stats, chart rankings, contacts and more on the Extend Podcast with Darshan Shah, MD podcast page.