About this episode

Dr. Steve Horvath discusses the science of biological aging and effective strategies to slow it down.

Get access to more than 200 episodes of my premium podcast (The Aliquot) when you sign up as a FoundMyFitness Premium Member The strongest anti-aging strategy may be less about dramatic reversal and more about removing what accelerates aging in the first place. In this episode, Dr. Steve Horvath maps out the science behind biological age and how aging clocks are changing the way researchers evaluate longevity interventions. He also explains why omega-3s, a daily multivitamin, and sufficient vegetable intake stand out as evidence-backed, compounding levers for shifting biological age over time. Timestamps: (00:00) Introduction (07:05) What exactly is biological aging? (12:39) Do all aging clocks measure the same thing? (18:22) PhenoAge vs. GrimAge—how methylation reveals mortality risk (20:27) Why GrimAge is a powerful mortality predictor (24:10) How your epigenome remembers long-term stress (28:08) Can parents pass stress to offspring through the epigenome? (30:12) Why standard aging clocks fail in sperm (31:35) Can lifestyle changes reverse GrimAge? (33:24) How DunedinPACE tracks your aging speed (37:26) Which clock is best for testing longevity interventions? (39:47) Can…

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