FoundMyFitness

Get access to more than 200 episodes of my premium podcast (The Aliquot) when you sign up as a FoundMyFitness Premium Member The strongest anti-aging strategy may be less about dramatic reversal and more about removing what accelerates aging in the first place. In this episode, Dr. Steve Horvath maps out the science behind biological age and how aging clocks are changing the way researchers evaluate longevity interventions. He also explains why omega-3s, a daily multivitamin, and sufficient vegetable intake stand out as evidence-backed, compounding levers for shifting biological age over time. Timestamps: (00:00) Introduction (07:05) What exactly is biological aging? (12:39) Do all aging clocks measure the same thing? (18:22) PhenoAge vs. GrimAge—how methylation reveals mortality risk (20:27) Why GrimAge is a powerful mortality predictor (24:10) How your epigenome remembers long-term stress (28:08) Can parents pass stress to offspring through the epigenome? (30:12) Why standard aging clocks fail in sperm (31:35) Can lifestyle changes reverse GrimAge? (33:24) How DunedinPACE tracks your aging speed (37:26) Which clock is best for testing longevity interventions? (39:47) Can methylation clocks replace long-term mortality studies? (43:33) Which interventions most reliably reverse epigenetic age? (46:31) Can someone reverse biological age by 5 years in 7 months? (50:49) Can GrimAge predict when you'll die? (52:36) Why a younger GrimAge doesn't mean more years of life (57:21) What epigenetic clocks fail to capture (1:03:26) Why aging clocks measure more than just inflammation (1:06:02) Does younger blood rejuvenate the whole body? (1:09:52) Can calorie restriction really slow biological aging? (1:14:00) Do GLP-1 drugs reverse epigenetic age? (1:17:29) Can a daily multivitamin slow epigenetic aging? (1:26:11) Omega-3, vitamin D, and exercise—which slows aging best? (1:34:01) Does correcting vitamin D deficiency reverse age acceleration? (1:36:29) Vegetables vs. exercise—which matters more for epigenetic age? (1:42:04) Does red meat accelerate epigenetic aging? (1:43:44) How much exercise is needed to slow epigenetic aging? (1:51:05) Can heat exposure mimic exercise? (1:52:29) Does a lower core body temperature slow aging? (1:54:54) How sleep disruption shows up on aging clocks (1:56:25) The role of social connection in biological aging (2:02:55) Are consumer biological age tests worth it? (2:07:52) How to choose a reliable biological age test (2:12:38) Why two epigenetic age tests might give different results (2:17:27) Can AI build better aging clocks? (2:18:58) Partial reprogramming—can cells become younger without losing identity? (2:22:52) What partial reprogramming can (and can't) reverse (2:27:43) Do DNA mutations actually drive aging? (2:29:59) Why no single intervention can stop aging (2:34:29) Why genetics aren't your destiny (2:38:38) Steve Horvath's longevity routine (2:43:11) Does short-term stress accelerate epigenetic aging? Show notes are available by clicking here Watch this episode on YouTube

Download my "How to Train According to the Experts" guide Discover my premium podcast, The Aliquot Creatine is renowned for enhancing strength, but its benefits extend far beyond muscle power. In this episode, Dr. Darren Candow, a leading researcher with over 140 peer-reviewed publications, explores creatine's diverse physiological impacts, from bolstering cognitive resilience under stress to mitigating symptoms of depression and protecting against cognitive decline caused by sleep deprivation. He explains why the conventional dosage of 5 grams per day might be insufficient, and how higher doses (10–25 grams) could unlock additional therapeutic effects. Timestamps: (00:00) Introduction (04:34) What makes creatine effective for exercise performance? (08:01) The loss of explosive power with aging (09:36) How creatine speeds up recovery between sets (12:13) Two ways creatine boosts muscle strength (14:12) Why creatine might not speed typical weight-training recovery (16:38) Anti-catabolic effects (17:16) Why do men and women respond differently? (18:50) Dietary creatine vs. supplementation (19:36) Is creatine supplementation necessary—or optional? (21:05) Why plant-based may benefit most (22:15) Should creatine dosage change with age? (23:01) Loading vs. daily dosing (25:57) Why 5 grams might not be enough—other tissues (27:48) Can creatine prevent bone loss—even without weight training? (28:10) How creatine supports osteoblast activity (29:51) Preventing hip fractures with creatine (32:33) Creatine vs. bisphosphonates (36:21) Why creatine isn't just for weightlifters (38:52) Why stressed brains benefit most (40:57) Why brain aging accelerates demand (43:54) Why 10g per day might be the optimal dose (45:45) Why creatine counteracts sleep deprivation (48:53) Before vs. after concussion (51:17) Should dosage be adjusted by weight? (52:39) Does creatine improve sleep on training days? (55:34) Creatine for Alzheimer's and Parkinson's—does the science hold up? (57:08) Can creatine help with depression and anxiety? (1:00:24) The role of creatine and glutamine in preventing respiratory illness (1:02:40) Why creatine may enhance endothelial health and circulation (1:04:04) Creatine's role in cardiometabolic health (1:05:45) When does loading actually make sense? (1:06:51) Creatine's dual role—preserving muscle and enhancing recovery after injury (1:09:46) Is creatine effective without exercise? (1:12:01) Why creatine might improve male fertility (1:13:57) Is it safe for children? (1:17:21) Creatine supplementation during pregnancy (1:18:54) Could creatine boost motor skills in kids? (1:19:34) Creatine monohydrate vs. the rest (1:24:15) How to avoid digestive issues with creatine supplementation (1:26:56) Does timing matter—and should you cycle it? (1:28:32) Should you take creatine every day—or only workout days? (1:29:17) Why caffeine might blunt the effects (1:32:21) Does creatine increase body fat—or is that a myth? (1:33:08) Preventing cramps (the hydration myth) (1:34:33) Understanding the creatinine confusion—why creatine won't damage your kidneys (1:36:59) Why creatine is linked (wrongly?) to baldness (1:40:22) Debunking myths—sleep, cancer, urination (1:43:39) How creatine affects homocysteine levels (1:46:32) Creatine and protein—the ideal post-workout pair? (1:49:26) How to pick the best creatine supplement (1:51:46) What to know about micronized creatine Watch this episode on YouTube Show notes are available by clicking here

Download my "How to Train According to the Experts" guide Exercise is more than a tool for physical transformation—it's a cornerstone of longevity, metabolic resilience, and neurocognitive vitality. In this special episode, I'm joined by Brady Holmer, a distinguished exercise science communicator and lifelong endurance runner, as we deconstruct the latest evidence-based protocols for enhancing muscle strength and cardiovascular health. What's the optimal exercise protocol to reverse 20 years of heart aging? Is the standard 150 minutes per week truly enough to preserve a youthful heart, or do you need to exercise more frequently? What's the most time-efficient way to build strength and muscle? We cut through the noise to deliver actionable insights that will transform your approach to training. This episode is accompanied by How to Train According to the Experts — a free, science-backed guide curating evidence-based strategies for optimizing aerobic fitness, strength, and metabolic health. Distilling protocols from leading researchers, it provides actionable frameworks for lifelong vitality. Download it now at howtotrainguide.com Timestamps: (00:00) Introduction (03:35) Why your training goals matter (06:23) Are 3 weeks of bed rest worse for fitness than 30 years of aging? (08:24) How to measure cardiorespiratory fitness (11:19) Why VO2 max is a marker of longevity (14:23) The role of VO2 max in endurance training (17:26) How to improve lactate clearance (18:47) Why zone 2 training may not improve VO2 max (22:42) How to measure training zones 1-5 (28:29) Smart watches vs. chest straps for heart rate (31:43) Benefits of zone 2 training (35:31) Can you combine HIIT and zone 2 in one workout? (40:53) Adjusting the 80/20 rule for time efficiency (45:13) Evidence-based HIIT protocols (49:22) How variation in interval training boosts fitness adaptations (51:07) Why the heart stiffens with age (54:09) How much exercise do you need? (1:00:31) Why exercise should be a daily priority (1:02:16) The exercise protocol that reversed 20 years of heart aging (1:07:24) Dr. Benjamin Levine's prescription for life (1:10:11) Brady & Rhonda's exercise routines (1:14:51) HIIT vs. zone 2 for mitochondrial health (1:17:39) How exercise intensity impacts fat burning (1:21:50) Does zone 2 make you a better "fat burner"? (1:27:04) Why HIIT outshines zone 2 for glucose regulation (1:31:00) The benefits of interval walking for glucose regulation (1:32:24) Why training for brain health is all about intensity (1:36:20) How short bursts of activity can extend your lifespan (1:40:04) Why "exercise snacks" lower the barriers to fitness (1:42:27) An alternative to caffeine for fighting midday slumps (1:43:32) The benefits of timing "exercise snacks" around meals (1:45:38) How muscle mass and strength decline with age (1:48:19) The age-related loss of muscle power (powerpenia) (1:50:04) General resistance training principles (1:57:01) Why compound exercises are best for building strength (2:00:05) Why rest intervals are crucial when strength training (2:02:02) How lifting heavy improves mental resilience (2:05:26) Should you train to failure? (2:08:57) Why strength training isn't a replacement for cardio (2:12:16) Training for muscle hypertrophy (2:17:38) Training and diet strategies for body recomposition (2:22:52) Time-efficient resistance training protocols (2:27:38) Why the interference effect is a myth (2:29:32) The minimum effective dose for strength and hypertrophy (2:31:16) How sauna use improves cardiorespiratory fitness (2:36:17) Why heat exposure supports resistance training, unlike cold (2:39:06) Can omega-3s prevent muscle loss during disuse? (2:41:21) Protein timing, distribution, and its impact on hypertrophy (2:46:53) Creatine supplementation Show notes are available by clicking here Watch this episode on YouTube

Discover my premium podcast, The Aliquot Learn how to choose the right omega-3 supplement in my free 13-page guide Exercise, meal timing, and sleep are three powerful tools for optimizing metabolic health, a key factor in healthy aging. Even slightly elevated blood glucose levels, but within the "normal" range, can contribute to brain atrophy in areas linked to aging and neurodegeneration. Long-term glucose elevations (high HbA1c) also promote harmful compounds that stiffen blood vessels, reduce heart flexibility, and raise cardiovascular risk. In this episode, recorded at the American Academy of Anti-Aging Medicine conference in Palm Beach, Florida, I provide practical, science-backed protocols on how to implement HIIT, circadian-timed eating, and optimized sleep strategies to dramatically improve metabolic health and protect against these harmful effects. Timestamps: (00:00) Introduction (04:25) Why HIIT outshines zone 2 for improving metabolic health (06:46) The signaling role of lactate production by muscle (09:33) Optimal HIIT conditions for improving body composition (10:36) How vigorous exercise repairs dysfunctional mitochondria (14:27) HIIT vs. zone 2 for mitochondrial biogenesis (16:09) Evidence-based HIIT protocols (17:46) Why "exercise snacks" are a crucial pre- and post-mealtime activity (19:50) The mortality benefits of short exercise bursts (23:08) Why late-night eating is detrimental (27:37) Can high glucose levels accelerate brain atrophy? (28:30) How circadian misalignment affects postprandial glucose (29:46) Metabolic health benefits of time-restricted eating (32:24) Why early eating is better for metabolic health (34:48) Why losing sleep for 3 nights mimics type 2 diabetes (36:58) Why less than 7 hours of sleep increases type 2 diabetes risk (37:44) Why chronically high blood glucose damages cardiovascular health (39:39) What 4 hours of sleep for 4 nights does to insulin signaling (40:44) Why short sleep facilitates obesity (42:03) The checklist for good sleep hygiene (45:37) Can 1 hour of extra sleep help you lose weight? (46:47) Cognitive behavioral therapy for insomnia (CBT-I) (48:22) How HIIT improves metabolic health when sleep-restricted (50:55) Can HIIT ameliorate the mortality risk from poor sleep? Show notes are available by clicking here Watch this episode on YouTube

Get my exact protocols for boosting levels of brain-derived neurotrophic factor (BDNF) and enhancing cognition Discover my premium podcast, The Aliquot Dr. Layne Norton is a Ph.D. in Nutritional Sciences, a professional bodybuilder, and a champion powerlifter. We discuss why most people aren't training too hard, when to go to failure, whether seed oils are "the" central cause of chronic disease, why having a slow metabolism isn't a credible reason for being overweight (for most), and the sustaining power of good habits. We also get into controversies around the carnivore diet, diet sodas, artificial sweeteners, intermittent fasting, and much more. Timestamps: (00:00) Introduction (04:48) Layne's coaching philosophy (14:39) Why to start tracking calories (for at least 3 days) (17:41) Why people lie to themselves about food intake (23:06) The profound benefits of small exercise doses (26:53) Why you should treat exercise like brushing your teeth (30:11) Benefits of resistance training for older individuals (33:51) Should you train to failure? (47:07) Why hard training & consistency trump exercise selection (56:46) Is lifting heavy necessary for building muscle? (57:54) Barbell vs. hack squats for preventing falls (1:00:10) Can lifting weights decrease low-back pain? (1:01:43) Injury prevention when resistance training (1:11:16) How exposure therapy can help you with injuries (1:15:04) Why pain doesn't always indicate tissue injury (1:18:17) Should you resistance train after a poor night of sleep? (1:21:57) Why menopause can cause weight gain (1:29:36) Why it's never too late to start lifting weights (1:32:05) Resistance training tips for older individuals with joint pain (1:36:18) Why total protein intake matters more than distribution (1:44:19) Layne's daily protein distribution (1:46:44) The shortcomings of nutrition studies (1:54:06) Is consuming more than 1.6 g/kg of protein beneficial? (1:55:33) Should you eat more protein in a calorie deficit? (1:56:43) Protein intake for endurance athletes (1:58:07) How much protein does Layne eat? (1:59:11) Are seed oils a predominant cause of chronic disease? (2:08:45) Does the carnivore diet increase heart disease risk? (2:14:16) Are heated seed oils more inflammatory? (2:20:33) Is there a "big food" industry conspiracy? (2:26:17) Are sugar-sweetened beverages uniquely deleterious? (2:30:17) Can diet soda help you lose weight? (2:34:20) Microbiome & cancer risks of diet soda (2:42:02) Is drinking 1 Diet Coke per day unhealthy? (2:44:24) Why Layne rarely takes a strong position on early science (2:49:04) Carnivore diet (3:01:52) Time-restricted eating (3:12:38) Layne's daily routine (3:16:55) Layne's diet and supplements (3:19:49) Creatine and hair loss (3:22:49) Rhodiola rosea & ashwagandha (3:25:54) Layne's tier 2 supplements Show notes are available by clicking here Watch this episode on YouTube

My omega-3 guide on concerns like a-fib, dosage, supplement quality, oxidation, and more Discover my premium podcast, The Aliquot Join over 300,000 people and sign up for my newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more In this special solo episode of FoundMyFitness, we're taking a deep dive into alcohol. We'll explore the science, misconceptions, controversies, and health effects of this widely used drug. I believe that a nuanced, scientific discussion on alcohol is the best way to provide you with the information you need to make an informed decision about alcohol use. Timestamps (00:00) Introduction (08:03) What does it mean to "have a drink"? (09:39) Drinking frequency definitions (12:39) How alcohol is metabolized (18:25) Can alcoholism be inherited? (19:41) How food affects alcohol metabolism (21:40) Does age affect alcohol metabolism? (22:29) How alcohol affects nutrient absorption (27:04) How alcohol affects gut health (28:57) Alcohol elevates circulating LPS levels (31:51) Gut health & alcohol use disorders (36:30) Sick quitter & healthy user biases (39:38) How alcohol impacts the brain (43:34) Alcohol's effects on anxiety (49:56) Alcohol facilitates thiamine deficiency (51:39) Alcohol promotes brain inflammation (52:56) Dementia & Alzheimer's disease risk (1:06:50) Is resveratrol in red wine beneficial? (1:11:28) How alcohol impacts sleep (1:19:47) Mitigating alcohol's impact on sleep (1:22:13) Hangover symptoms & causes (1:26:33) How congeners affect hangover severity (1:27:58) Treating hangovers with fruit (1:30:40) Zinc, vitamin B3, & hangovers (1:31:41) Managing hangovers with NSAIDs (1:32:22) "Hair of the dog" for hangovers (1:32:40) Liposomal glutathione, NAC, & hangovers (1:35:56) Does ZBiotics prevent hangovers? (1:38:18) Dihydromyricetin (DHM) for hangovers (1:39:15) Exercise & sauna for treating hangovers (1:40:21) Alcohol's effect on mortality risk (1:44:28) Alcohol consumption in Blue Zones (1:49:07) Does alcohol increase cancer risk? (2:00:43) Can quitting alcohol lower cancer risk? (2:09:46) Alcohol & cardiovascular disease (CVD) (2:23:24) Alcohol and type 2 diabetes risk (2:28:28) Alcohol's impact on your waistline (2:31:33) Why alcohol facilitates weight gain (2:34:06) How alcohol impacts reproductive health (2:44:31) Preconception alcohol risks (2:47:12) How alcohol affects testosterone in men (2:48:55) Pre-pregnancy alcohol consumption risks (2:53:17) Is red wine the healthiest option? (2:57:47) Alcohol & post-exercise recovery (3:01:34) Does alcohol "blunt your gains"? (3:04:11) The BEER-HIIT study (3:05:03) Can exercise lessen alcohol cravings? (3:12:57) Alcohol damage control tactics Show notes are available by clicking here Watch this episode on YouTube

Download the 13-Page "Omega-3 Supplementation Guide" Discover my premium podcast, The Aliquot Join over 300,000 people and sign up for my newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more Today's guest, Dr. Benjamin Levine, has shown that with the right exercise protocol, people who were sedentary most of their lives could reverse up to 20 years of heart aging. Dr. Levine is one of the world's leading experts in understanding how the heart adapts under a variety of conditions, whether that's exercise, elite athleticism, or hospital bedrest. Or even highly exotic conditions, like prolonged exposure to microgravity. He is the founding director of the Institute for Exercise and Environmental Medicine at UT Southwestern in Dallas. Timestamps (00:00) Introduction (06:21) Bed rest vs. aging (11:40) Does exercise protect against long COVID? (17:14) How 12 weeks of bed rest affects heart size (18:42) Why a brand-new rubber band mimics a lifetime of endurance training (22:14) The exercise dose that preserves youthful cardiovascular structure (24:22) The exercise regimen that reversed 20 years of heart aging (28:05) What it takes to reverse vascular age by 15 years (33:29) Benefits of starting an exercise regimen in your 70s (39:17) Risks of high-intensity exercise (42:42) Balancing high-intensity & moderate-intensity training (47:39) Training for health vs. training for performance (49:58) Make exercise a part of your personal hygiene (51:01) Why does VO2 max correlate with longevity? (58:29) The 2018 JAMA study on cardiorespiratory fitness & mortality (1:04:06) How does change in fitness over time affect mortality? (1:06:19) Why exercise non-responders should consider "increasing the dose" (1:10:08) The 2 limiting factors for improving VO2 max in competitive athletes (1:17:20) Heart adaptations in purely strength-trained vs. endurance athletes (1:23:09) Why pure strength-trainers should incorporate endurance training (1:26:53) How strength training affects blood pressure (1:31:27) How exercise influences cardiac output in mitochondrial myopathy patients (1:33:25) Does CrossFit count as endurance training? (1:35:50) What's the best exercise for improving blood pressure? (1:40:57) Lifestyle strategies for treating hypertension (1:43:26) Why recovery is key to reaping the benefits of a training stimulus (1:47:22) The best indicator of being overtrained (1:54:46) Why HRV is a poor indicator of recovery (2:00:02) Why do men tend to be faster runners than women? (2:03:34) Can women achieve similar aerobic exercise benefits doing 2x less than men? (2:05:06) Are there cardiovascular benefits of HRT in women? (2:08:45) Exercise volume vs. coronary plaque calcification (2:15:35) How exercise duration & intensity affect coronary calcium levels (2:18:48) Why high exercise duration & intensity increases risk of Afib (2:26:00) Why you shouldn't become an endurance athlete to "live longer" Watch this episode on YouTube Show notes are available by clicking here

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more Discover my premium podcast, The Aliquot If you've been following FoundMyFitness for a while, you may remember that we have our members-only podcast, The Aliquot. I want to share a preview of our newest Aliquot episode, "The Science of Optimizing Sleep," available to everyone, not just our Premium Members. Adequate, quality sleep is essential for the body's recovery and repair, promoting optimal physical and mental health. Getting a good night's sleep can be challenging, especially in our modern world, but we can take steps to overcome those challenges. In this Aliquot, we present a mashup of our best resources on sleep, featuring insights from Dr. Matthew Walker, Dr. Satchin Panda, and me. In this preview, we discuss: (00:02:13) How exercise timing affects deep sleep (00:08:03) Do saunas and hot baths increase sleep-enhancing hormones? (00:12:33) Can learning and meditation boost deep sleep? (00:14:10) Do scented oils, like lavender, impact sleep? (00:14:47) The insulin-tryptophan-melatonin connection (00:19:20) Why carb-heavy meals make us sleepy In the full episode available only for Premium Members, we also discuss: Can calming music, akin to lullabies, curb pre-sleep ruminations? The effect of air quality on sleep The effect of low-level noise on sleep fragmentation Whether or not time in nature transforms sleep quality Could melatonin supplementation increase REM sleep — at the cost of decrease deep sleep? How my sauna and hot tub routine preps me for sleep Is there evidence white noise helps sleep and can calming music curb pre-sleep ruminations? The differential impact of morning vs. evening light in slow wave sleep Can adjusting our body's thermal cues unlock deeper sleep? (increase deep sleep) Improving sleep with science-backed heat therapy protocols and how my sauna and hot tub routine preps me for sleep The four pillars of sleep How much sleep is enough? (from newborns to older adults) The surprising lifestyle factors that synergize to maintain glymphatic clearance in aging brains (sleep, exercise, and omega-3s) Are modern lifestyles and "social jetlag" turning us into shift workers? Building resilience against circadian disruptions Five immediate steps to enhance sleep quality tonight How long caffeine stays in the system The effect of alcohol and marijuana on sleep, particularly REM sleep