Is chronic fatigue a gut-brain reflex? (Big Ideas in Neuroscience) | Julia Kaltschmidt

Is chronic fatigue a gut-brain reflex? (Big Ideas in Neuroscience) | Julia Kaltschmidt

July 16, 2026 · 36 min · Season 9 · Episode 12

About this episode

Julia Kaltschmidt discusses the gut-brain circuitry related to chronic fatigue and the body's sickness reflex.

Why does being sick make you so exhausted – and why does that exhaustion sometimes outlast the illness itself? Today, neuroscientist Julia Kaltschmidt returns to the podcast to talk about the body's hidden "sickness reflex," the gut-brain circuitry behind it, and what those things might reveal about chronic fatigue. Kaltschmidt, a Wu Tsai Neurosciences Institute faculty scholar and professor of neurosurgery at Stanford Medicine, is an expert on the enteric nervous system — the gut's own semi-...

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