Is neurodegeneration a waste-management problem? | Monther Abu-Remaileh
About this episode
The episode discusses the potential misinterpretation of plaques in neurodegeneration as a waste-management issue rather than a direct cause of brain disorders.
For decades, the field focused on the plaques and tangles of misfolded proteins that show up in the brains of patients with Alzheimer’s, Parkinson’s and other disorders. The natural assumption was that if you could design a drug to clear out that gunk, you could save the brain. But so far, that bet hasn't paid off. Now, researchers are taking a big step back and asking whether the plaques aren't a culprit, but rather a clue pointing to something more fundamental going wrong in our brain cells...
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