Season 5 Episode 9: Rethinking the Design and Conduct of Kidney Trials

Season 5 Episode 9: Rethinking the Design and Conduct of Kidney Trials

November 21, 2025 · 11 min · Season 5 · Episode 9

About this episode

Experts discuss the evolution of clinical trial design in nephrology, emphasizing patient-centered outcomes and strategies for better kidney care.

Clinical trial design in nephrology is evolving. In this episode, leading experts explore why a paradigm shift is needed from traditional biomarkers to patient-centered outcomes and practical strategies for advancing trial implementation. This conversation draws on insights from the ISN Consensus Meeting on Changing Paradigms of Studies in CKD (Vancouver, Nov 22-23, 2024) where clinicians, trialists, patient partners, regulators and industry scientists came together to rethink trial endpoints, outcomes and designs. Together, they discuss how reimagining kidney trials can generate more relevant, equitable, and actionable evidence for better kidney care worldwide. Participants Adeera Levin Professor of Medicine, University of British Columbia, Canada, and Past-President of the International Society of Nephrology (ISN). Dr. Levin is a global leader in kidney health research, with extensive experience in chronic kidney disease (CKD) management, clinical trials, and international health system strengthening. Jennifer Lees Senior Clinical Lecturer and Honorary Consultant Nephrologist at the University of Glasgow, UK. Dr. Lees’ research focuses on improving patient outcomes in kidney…

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