About this episode

The episode discusses how estrogen decline affects energy levels in women during perimenopause and explores solutions involving Urolithin A.

Most women in perimenopause assume their energy crash is a sleep or a stress problem. Jen Scheinman, Head of Nutrition Affairs at Timeline, explains what the real reason is, and why estrogen loss makes it dramatically worse for women than men. If you have been doing everything right and still feel like you are running on empty, this episode explains what is actually happening at the cellular level, and what women in midlife can do about it. WHAT YOU’LL LEARN • Why women's energy levels drop faster in perimenopause? • When does mitochondrial decline start and how fast does it progress? • What is Urolithin A and why can't you get enough from food? • What is mitophagy and why does it matter for energy after 40? • Does Urolithin A build new mitochondria or just clear out damaged ones? • What is the right dose of Urolithin A and does timing matter? • Can Urolithin A reduce fine lines and improve skin in perimenopause? • What does the research say about Urolithin A and immune aging? • Should you take Urolithin A as a supplement and use it topically? • Can Urolithin A help with brain fog after 40? VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually…

People in this episode

Host: Angela Foster

Guest: Jen Scheinman

Topics covered

• perimenopause
• energy levels
• mitochondrial health
• Urolithin A
• mitophagy
• women's health

Keywords

• perimenopause
• energy crash
• mitochondrial decline
• Urolithin A
• mitophagy
• women's health
• brain fog
• immune aging

Sponsors

Timeline Mitopure

Mentioned in this episode

Organizations: Timeline

Products: Urolithin A

More episodes of High Performance Health

• Always Bloated, Foggy, and Exhausted in Perimenopause? Your Cell Membranes May Be Why | Jessica Kane · April 24, 2026 · 1h 2m
• Why Eating Tomatoes Shrinks Belly Fat in Perimenopause (The Brown Fat Trigger) | Dr. William Li · April 24, 2026 · 14 min
• Why Your Gut Is the Missing Link in Perimenopause | Cynthia Thurlow · April 20, 2026 · 1h 10m
• The Real Reason Women Over 40 Can't Lose Abdominal Fat (It's Not Calories) | Sarah Berry · April 17, 2026 · 8 min
• Why Leg Strength Is the Best Predictor of Brain Health for Women Over 40 | Dr. Tommy Wood · April 10, 2026 · 8 min
• Perimenopause Doctor: This is how you Fix Belly Fat, Brain Fog and Bloating with Mary Claire Haver, M.D · April 6, 2026 · 39 min

Explore listener stats, chart rankings, contacts and more on the High Performance Health podcast page.